Abstract
Purpose of Review: The balance between inflammation and its resolution plays an important and increasingly appreciated role in heart failure (HF) pathogenesis. In humans, different chronic inflammatory conditions and immune-inflammatory responses to infection can lead to diverse HF manifestations. Reviewing the phenotypic and mechanistic diversity of these HF presentations offers useful clinical and scientific insights. Recent Findings: HF risk is increased in patients with chronic inflammatory and autoimmune disorders and relates to disease severity. Inflammatory condition–specific HF manifestations exist and underlying pathophysiologic causes may differ across conditions. Summary: Although inflammatory disease–specific presentations of HF differ, chronic excess in inflammation and auto-inflammation relative to resolution of this inflammation is a common underlying contributor to HF. Further studies are needed to phenotypically refine inflammatory condition–specific HF pathophysiologies and prognoses, as well as potential targets for intervention.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 267-278 |
| Number of pages | 12 |
| Journal | Current heart failure reports |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 2022 |
Funding
N.B. is supported by the Stimulating Access to Research in Residency of the National Institutes of Health under Award Number R38AI140299. M.J.F. is supported by the National Institutes of Health Award Numbers R01HL156792 and R01HL154862. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Keywords
- Chronic inflammatory and autoimmune disorders
- Heart failure pathogenesis
- Inflammation resolution
- Persistent inflammation
- Trained immunity
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Physiology (medical)
- Emergency Medicine