Heart failure patients have enhanced cerebral autoregulation response in acute ischemic stroke

Pedro Castro*, Jorge Serrador, Isabel Rocha, Paulo Castro Chaves, Farzaneh Sorond, Elsa Azevedo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The cerebrovascular effects of a failing heart-pump are largely unknown. Chronic heart failure (HF) might cause pre-conditioning effect on cerebral hemodynamics but not study so far in acute stroke. We aimed to investigate if HF induces effects in dynamic cerebral autoregulation (CA), within 6 h of symptom-onset through chronic stage of ischemic stroke. We enrolled 50 patients with acute ischemic stroke. Groups with (N = 8) and without HF and 20 heathy controls were compared. Arterial blood pressure (Finometer) and cerebral blood flow velocity (transcranial Doppler) were monitored within 6 and at 24 h from symptom-onset and at 3 months. We assessed dynamic CA by transfer function analysis and cardiac disease markers. HF associated with higher phase (better dynamic CA) at ischemic hemisphere within 6 (p = 0.042) and at 24 h (p = 0.006) but this effect was not evident at 3 months (p ' 0.05). Gain and coherence trends were similar between groups. We found a positive correlation between phase and admission troponin I levels (Spearman’s r = 0.348, p = 0.044). Our findings advances on the knowledge of how brain and heart interact in acute ischemic stroke by showing a sustained dynamic cerebral autoregulation response in HF patients mainly with severe aortic valve disease. Understanding the physiological mechanisms that govern this complex interplay can be useful to find novel therapeutic targets which can improve outcome in ischemic stroke.

Original languageEnglish (US)
Pages (from-to)753-761
Number of pages9
JournalJournal of thrombosis and thrombolysis
Issue number3
StatePublished - Oct 1 2020


  • Autoregulation
  • Cerebral infarction
  • Heart failure
  • Stroke
  • Ultrasound

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology


Dive into the research topics of 'Heart failure patients have enhanced cerebral autoregulation response in acute ischemic stroke'. Together they form a unique fingerprint.

Cite this