Heart Failure With Recovered Left Ventricular Ejection Fraction: JACC Scientific Expert Panel

Jane E. Wilcox*, James C. Fang, Kenneth B. Margulies, Douglas L. Mann

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Reverse left ventricular (LV) remodeling and recovery of LV function are associated with improved clinical outcomes in patients with heart failure with reduced ejection fraction. A growing body of evidence suggests that even among patients who experience a complete normalization of LV ejection fraction, a significant proportion will develop recurrent LV dysfunction accompanied by recurrent heart failure events. This has led to intense interest in understanding how to manage patients with heart failure with recovered ejection fraction (HFrecEF). Because of the lack of a standard definition for HFrecEF, and the paucity of clinical data with respect to the natural history of HFrecEF patients, there are no current guidelines on how these patients should be followed up and managed. Accordingly, this JACC Scientific Expert Panel reviews the biology of reverse LV remodeling and the clinical course of patients with HFrecEF, as well as provides guidelines for defining, diagnosing, and managing patients with HFrecEF.

Original languageEnglish (US)
Pages (from-to)719-734
Number of pages16
JournalJournal of the American College of Cardiology
Volume76
Issue number6
DOIs
StatePublished - Aug 11 2020

Keywords

  • heart failure with recovered ejection fraction
  • myocardial recovery

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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