@article{eec5a05758ab4cf9add9946dd489e953,
title = "Heart rate: A risk factor for cancer?",
abstract = "The relationship between heart rate and cancer mortality was examined in 3 Chicago epidemiologic studies: 1233 white men originally age 40-59 followed 18 years from the Chicago Peoples Gas Company study; 1899 white men originally age 40-55 followed 17 years from the Chicago Western Electric Company study; 5784 white men originally age 45-64 followed 5 years from the Chicago Heart Association Detection Project in Industry. There was a significant association between heart rate and cancer mortality in both univariate and muftivariate analyses in men from the Gas Company study and in men from the Chicago Heart Association study, but there was no association between heart rate and cancer mortality in men from the Western Electric study. The relationship persisted in the Gas Company study but not in the Chicago Heart Association study after eliminating deaths within the first 2 years of follow-up. With cancer deaths broken down by site, mortality from lung and colon cancer in the Gas Company study and mortality from lung cancer in the Chicago Heart Association study were significantly associated with baseline heart rate on univariate analysis and on bivarlate analysis controlling for age. Only colon cancer in the Gas Company, however, remained associated with heart rate when other variables were controlled. Thus, in 2 of the 3 studios examined, heart rate appeared to be an independent risk factor for cancer mortality in men.",
keywords = "Death, Head rate, Neoplasms",
author = "Victoria Perskly and Dyer, {Alan R.} and Jolita Leonas and Jeremiah Stamler and Berkson, {David M.} and Lindberg, {Howard A.} and Oglesby Paul and Shekelle, {Richard B.} and Lepper, {Mark H.} and Schoenberger, {James A.}",
note = "Funding Information: This work was done while Dr. Dyer was an Established Investigator of the American Heart Association and Ms. Leonas was a Fellow supported by grant no. 5 T32HL 07113 from the National Heart, Lung, and Blood Institute. It was also carried out as a com- ponent of the epidemiologic research program of the Northwestern University Cancer Center. The work of the Chicago Heart Association Detection Project in Industry was accomplished through the invaluable cooperation of many Chicago corn-panies and organizations. Acknowledgment is gratefully made to the staff and volunteers in the Chicago Heart Association serving the Project: Louis DeBoer and Ray Restivo, Executive Directors, and Kay Westfall, Program Director; the Chicago Heart Association Detection Project in Industry staff: Thelma Black, Clarice Blanton, Joan Carothers, Pamela Desmond, Arlene Dungca, Mary Ann Foelker, Susan Forkos, Carol Fulgenzi, Harold Gram, Jean Graver, Inger Hansen, Cherry Latimer, Mary Newman, Peggy Powell, Karen Strentz, R.N., and Suzann Ward, R.N.; also, the volunteer members of the Heart Disease Committee of the Chicago Heart Association and its subcommittees: Dr. Howard Adler, Dr. Rene Arcilla, Dr. Robert Arzoecher, Dr. Richard Funding Information: This research was supported by grants from the Chicago Heart Association, American Heart Association, Illinois Heart Association, Illinois Regional Medical Program and by grants no. 2 RO 1 HL15174 and 5 RO 1 HL21020 from the National Heart, Lung, and Blood Institute ofthe US Public Health Service.",
year = "1981",
month = oct,
doi = "10.1093/oxfordjournals.aje.a113213",
language = "English (US)",
volume = "114",
pages = "477--487",
journal = "American journal of epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "4",
}