Abstract
Background: Depression is associated with an increased risk for cardiac morbidity and mortality in patients with coronary heart disease (CHD). Cardiac autonomic nervous system (ANS) dysregulation, proinflammatory processes, and procoagulant processes have been suggested as possible explanations. Methods: Heart rate variability (HRV), an indicator of cardiac autonomic regulation, and markers of inflammation [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)] and coagulation (fibrinogen) were assessed in 44 depressed patients with CHD. Results: Moderate, negative correlations were found between fibrinogen and four measures of HRV. IL-6 also negatively correlated with one measure of HRV (total power) and was marginally related to two others (very low frequency and low frequency power). Neither CRP nor TNF-α was significantly related to any measure of HRV. Conclusions: The finding that fibrinogen and IL-6 are moderately related to HRV suggests a link between these factors in depressed CHD patients. The relationship between ANS function and inflammatory and coagulant processes should be investigated in larger mechanistic studies of depression and cardiac morbidity and mortality.
Original language | English (US) |
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Pages (from-to) | 463-467 |
Number of pages | 5 |
Journal | Journal of Psychosomatic Research |
Volume | 62 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2007 |
Funding
This research was supported by Grant No. R01 HL65356 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; the Lewis and Jean Sachs Charitable Lead Trust; and the National Alliance for Research on Schizophrenia and Depression (GEM).
Keywords
- Autonomic nervous system
- Coagulation
- Depression
- Heart disease
- Inflammation
ASJC Scopus subject areas
- Clinical Psychology
- Psychiatry and Mental health