Heart rate variability associated with acute exercise challenge in children with sickle cell anaemia

Stephan L. Kienzle; Mark Rodeghier; Robert I. Liem

doi:10.1111/bjh.17834

Heart rate variability associated with acute exercise challenge in children with sickle cell anaemia

Stephan L. Kienzle, Mark Rodeghier, Robert I. Liem^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

We examined heart rate variability (HRV) during exercise testing in 20 children with sickle cell anaemia (SCA) and 12 controls. Subjects achieved lower median HRV at peak exercise [standard deviation of R-wave to R-wave intervals (SDNN), 2·3 vs 2·9 ms, P = 0·027; logarithmic transformation of high frequency power (lnHF), 0·9 vs 1·3 ln(ms²), P = 0·047] and had lower post-exercise HRV across minute-by-minute analysis of recovery. After adjustment for haemoglobin, fitness and SCA status, subjects had lower HRV at the end of recovery with differences increasing as baseline HRV increased. Further investigation of HRV and exercise safety in SCA is warranted.

Original language	English (US)
Pages (from-to)	397-401
Number of pages	5
Journal	British Journal of Haematology
Volume	196
Issue number	2
DOIs	https://doi.org/10.1111/bjh.17834
State	Published - Jan 2022

ASJC Scopus subject areas

Hematology

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10.1111/bjh.17834

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title = "Heart rate variability associated with acute exercise challenge in children with sickle cell anaemia",

abstract = "We examined heart rate variability (HRV) during exercise testing in 20 children with sickle cell anaemia (SCA) and 12 controls. Subjects achieved lower median HRV at peak exercise [standard deviation of R-wave to R-wave intervals (SDNN), 2·3 vs 2·9 ms, P = 0·027; logarithmic transformation of high frequency power (lnHF), 0·9 vs 1·3 ln(ms2), P = 0·047] and had lower post-exercise HRV across minute-by-minute analysis of recovery. After adjustment for haemoglobin, fitness and SCA status, subjects had lower HRV at the end of recovery with differences increasing as baseline HRV increased. Further investigation of HRV and exercise safety in SCA is warranted.",

author = "Kienzle, {Stephan L.} and Mark Rodeghier and Liem, {Robert I.}",

note = "Funding Information: The authors would like to thank Michael Carroll, Connie Casale and the staff in the Ann & Robert H. Lurie Children{\textquoteright}s Hospital of Chicago Cardiopulmonary Exercise Laboratory for their assistance with this study. This work is funded by the National Institutes of Health and the National Heart, Lung, and Blood Institute (5R01 HL136480, Liem). Publisher Copyright: {\textcopyright} 2021 British Society for Haematology and John Wiley & Sons Ltd",

year = "2022",

month = jan,

doi = "10.1111/bjh.17834",

language = "English (US)",

volume = "196",

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AU - Kienzle, Stephan L.

AU - Rodeghier, Mark

AU - Liem, Robert I.

N1 - Funding Information: The authors would like to thank Michael Carroll, Connie Casale and the staff in the Ann & Robert H. Lurie Children’s Hospital of Chicago Cardiopulmonary Exercise Laboratory for their assistance with this study. This work is funded by the National Institutes of Health and the National Heart, Lung, and Blood Institute (5R01 HL136480, Liem). Publisher Copyright: © 2021 British Society for Haematology and John Wiley & Sons Ltd

PY - 2022/1

Y1 - 2022/1

N2 - We examined heart rate variability (HRV) during exercise testing in 20 children with sickle cell anaemia (SCA) and 12 controls. Subjects achieved lower median HRV at peak exercise [standard deviation of R-wave to R-wave intervals (SDNN), 2·3 vs 2·9 ms, P = 0·027; logarithmic transformation of high frequency power (lnHF), 0·9 vs 1·3 ln(ms2), P = 0·047] and had lower post-exercise HRV across minute-by-minute analysis of recovery. After adjustment for haemoglobin, fitness and SCA status, subjects had lower HRV at the end of recovery with differences increasing as baseline HRV increased. Further investigation of HRV and exercise safety in SCA is warranted.

AB - We examined heart rate variability (HRV) during exercise testing in 20 children with sickle cell anaemia (SCA) and 12 controls. Subjects achieved lower median HRV at peak exercise [standard deviation of R-wave to R-wave intervals (SDNN), 2·3 vs 2·9 ms, P = 0·027; logarithmic transformation of high frequency power (lnHF), 0·9 vs 1·3 ln(ms2), P = 0·047] and had lower post-exercise HRV across minute-by-minute analysis of recovery. After adjustment for haemoglobin, fitness and SCA status, subjects had lower HRV at the end of recovery with differences increasing as baseline HRV increased. Further investigation of HRV and exercise safety in SCA is warranted.

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Heart rate variability associated with acute exercise challenge in children with sickle cell anaemia

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