Heat shock proteins, HSP25 and HSP70, and apoptosis in developing endocardial cushion of the mouse heart

Eltyeb Abdelwahid*, Minna Eriksson, Lauri J. Pelliniemi, Eero Jokinen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Formation of the atrioventricular channels and valves from the endocardial cushion occurs through growth and remodeling of the initial endocardial cushion. This process requires balanced coordination of proliferation and apoptosis by still unknown factors. To detect a possible role for the heat shock proteins 25 and 70 (HSP25 and HSP70) as apoptosis-associated proteins and differentiation factors in the development of the endocardial cushion, we analyzed their temporal and regional occurrence during cell proliferation and apoptosis in E11-E17 embryos. The distribution and timing of these events and factors were consistent with the hypothesis that HSP25 is related to myocardial development whereas HSP70 is related to differentiation of the endocardial cushion by cell proliferation and apoptosis.

Original languageEnglish (US)
Pages (from-to)95-104
Number of pages10
JournalHistochemistry and Cell Biology
Volume115
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Apoptosis
  • Developing heart
  • Endocardial cushion
  • Heat shock proteins
  • PCNA

ASJC Scopus subject areas

  • Histology
  • Molecular Biology
  • Medical Laboratory Technology
  • Cell Biology

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