Heating of Aqueous Dispersions Containing MnFe2O4 Nanoparticles by Radio-Frequency Magnetic Field Induction

Dong Hyun Kim; Ynhi T. Thai; David E. Nikles; Christopher S. Brazel

doi:10.1109/TMAG.2008.2005329

Heating of Aqueous Dispersions Containing MnFe2O4 Nanoparticles by Radio-Frequency Magnetic Field Induction

Dong Hyun Kim, Ynhi T. Thai, David E. Nikles, Christopher S. Brazel

Radiology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Our interest in identifying magnetic nanoparticles for magnetic hyperthermia therapy has led to this study of the ac magnetic field induced heating of MnFe₂O₄ nanoparticles. Single-crystal MnFe ₂O₄ nanoparticles with diameters ranging from 5.3 to 12.1 nm were synthesized by a thermal decomposition method. Oleic acid and oleylamine ligands used during synthesis were replaced by meso-2,3-dimercaptosuceinic acid, which allowed the particles to be dispersed in water. Magnetic field induction heating of aqueous dispersions of the particles showed that the value of specific absorption rate (SAR) increased with increasing particle size until it peaked for particles with an average diameter of 10.5 nm and then decreased for particles with an average diameter of 12.1 mn. Theoretical calculations of the effect of particle size on the heat generation were in agreement with this trend and showed that, with the largest particles, there was a decrease in the contribution of Brownian relaxation to the heating, leading to a decrease in the SAR for these particles.

Original language	English (US)
Article number	4760209
Pages (from-to)	64-70
Number of pages	7
Journal	IEEE Transactions on Magnetics
Volume	45
Issue number	1
DOIs	https://doi.org/10.1109/TMAG.2008.2005329
State	Published - Jan 1 2009

Keywords

Hyperthermia
Magnetic nanoparticles
MnFeO
Multifunctional nanoparticles
Specific absorption rate

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Electrical and Electronic Engineering

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10.1109/TMAG.2008.2005329

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title = "Heating of Aqueous Dispersions Containing MnFe2O4 Nanoparticles by Radio-Frequency Magnetic Field Induction",

abstract = "Our interest in identifying magnetic nanoparticles for magnetic hyperthermia therapy has led to this study of the ac magnetic field induced heating of MnFe2O4 nanoparticles. Single-crystal MnFe 2O4 nanoparticles with diameters ranging from 5.3 to 12.1 nm were synthesized by a thermal decomposition method. Oleic acid and oleylamine ligands used during synthesis were replaced by meso-2,3-dimercaptosuceinic acid, which allowed the particles to be dispersed in water. Magnetic field induction heating of aqueous dispersions of the particles showed that the value of specific absorption rate (SAR) increased with increasing particle size until it peaked for particles with an average diameter of 10.5 nm and then decreased for particles with an average diameter of 12.1 mn. Theoretical calculations of the effect of particle size on the heat generation were in agreement with this trend and showed that, with the largest particles, there was a decrease in the contribution of Brownian relaxation to the heating, leading to a decrease in the SAR for these particles.",

keywords = "Hyperthermia, Magnetic nanoparticles, MnFeO, Multifunctional nanoparticles, Specific absorption rate",

author = "Kim, {Dong Hyun} and Thai, {Ynhi T.} and Nikles, {David E.} and Brazel, {Christopher S.}",

note = "Funding Information: This work was supported by the University of Alabama{\textquoteright}s Alton Scott Memorial Fund and by an international grant to the first author by a Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-D00092).",

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AU - Brazel, Christopher S.

N1 - Funding Information: This work was supported by the University of Alabama’s Alton Scott Memorial Fund and by an international grant to the first author by a Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (KRF-2006-D00092).

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Our interest in identifying magnetic nanoparticles for magnetic hyperthermia therapy has led to this study of the ac magnetic field induced heating of MnFe2O4 nanoparticles. Single-crystal MnFe 2O4 nanoparticles with diameters ranging from 5.3 to 12.1 nm were synthesized by a thermal decomposition method. Oleic acid and oleylamine ligands used during synthesis were replaced by meso-2,3-dimercaptosuceinic acid, which allowed the particles to be dispersed in water. Magnetic field induction heating of aqueous dispersions of the particles showed that the value of specific absorption rate (SAR) increased with increasing particle size until it peaked for particles with an average diameter of 10.5 nm and then decreased for particles with an average diameter of 12.1 mn. Theoretical calculations of the effect of particle size on the heat generation were in agreement with this trend and showed that, with the largest particles, there was a decrease in the contribution of Brownian relaxation to the heating, leading to a decrease in the SAR for these particles.

AB - Our interest in identifying magnetic nanoparticles for magnetic hyperthermia therapy has led to this study of the ac magnetic field induced heating of MnFe2O4 nanoparticles. Single-crystal MnFe 2O4 nanoparticles with diameters ranging from 5.3 to 12.1 nm were synthesized by a thermal decomposition method. Oleic acid and oleylamine ligands used during synthesis were replaced by meso-2,3-dimercaptosuceinic acid, which allowed the particles to be dispersed in water. Magnetic field induction heating of aqueous dispersions of the particles showed that the value of specific absorption rate (SAR) increased with increasing particle size until it peaked for particles with an average diameter of 10.5 nm and then decreased for particles with an average diameter of 12.1 mn. Theoretical calculations of the effect of particle size on the heat generation were in agreement with this trend and showed that, with the largest particles, there was a decrease in the contribution of Brownian relaxation to the heating, leading to a decrease in the SAR for these particles.

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KW - Specific absorption rate

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Heating of Aqueous Dispersions Containing MnFe2O4 Nanoparticles by Radio-Frequency Magnetic Field Induction

Abstract

Keywords

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