Helicobacter pylori colonisation of duodenal foveolar metaplasia requires concurrent gastric infection

Adam L. Booth*, Raul S. Gonzalez

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Aims Evaluate the rate and significance of Helicobacter pylori (H. pylori) involving duodenal foveolar metaplasia of chronic peptic duodenitis (CPD). Methods We identified 100 biopsy cases of CPD with synchronous stomach biopsies. All 200 were reviewed for histological changes (eg, chronic gastritis, acute inflammation) and underwent immunohistochemical staining for H. pylori. Results were correlated with patient age, sex, endoscopy indication and findings on stomach biopsy. Results Cases included 49 men and 51 women, with a median age of 56 years. Reflux or dysphagia was the most common symptom. Chronic gastritis was present in 46 stomach biopsies, with 54 within normal limits. Twelve stomach biopsies showed H. pylori, all of which showed gastritis. Two duodenal biopsies (2%) demonstrated H. pylori organisms on immunohistochemistry, both from patients with H. pylori gastritis. Conclusions Routine examination of CPD samples for H. pylori appears unnecessary if a stomach biopsy is available for review.

Original languageEnglish (US)
Pages (from-to)537-539
Number of pages3
JournalJournal of Clinical Pathology
Issue number8
StatePublished - Aug 1 2021
Externally publishedYes


  • gastritis
  • gastrointestinal diseases
  • helicobacter
  • immunohistochemistry
  • intestine
  • small

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Helicobacter pylori colonisation of duodenal foveolar metaplasia requires concurrent gastric infection'. Together they form a unique fingerprint.

Cite this