Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: Nucleotide sequence of the mRNA predicts an N-terminal membrane anchor

S. W. Hiebert, R. G. Paterson, R. A. Lamb

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

The nucleotide sequence of a cloned cDNA copy of the mRNA coding for the hemagglutinin-neuraminidase of the paramyxovirus SV5 was determined. There was a single large open reading frame on the mRNA which encoded a protein of 565 amino acids with a molecular weight of 62,134. The deduced amino acid sequence indicated that the only major hydrophobic region in the protein sufficiently long to anchor the protein in the membrane is located near the N terminus (amino acids 18 to 36). It is suggested that, like the influenza virus neuraminidase, hemagglutinin-neuraminidase of paramyxoviruses is oriented with its N terminus inserted into the membrane.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of virology
Volume53
Issue number4
StatePublished - 1985

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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