TY - JOUR
T1 - Hemangiopericytoma of the liver
T2 - Immunohistochemical observations, expression of angiogenic factors, and review of the literature
AU - Flores-Stadler, Elbio M.
AU - Chou, Pauline M
AU - Walterhouse, David O
AU - Bourtsos, Eleni
AU - Gonzalez-Crussi, Frank
PY - 1997/9/1
Y1 - 1997/9/1
N2 - Purpose: We describe an unusual case of a hemangiopericytoma in the liver of a child, review the literature, and characterize the tumor by immunohistochemistry and electron microscopy. We study the expression of basic fibroblast growth factor (bFGF) and of vascular endothelial growth factor (VEGF) in the tumor. Materials and Methods: Clinical history and pathology were reviewed; sections of the tumor were studied by histology, electron microscopy, and immunohistochemistry using antibodies directed towards Factor-XIIIa, HAM-56, bFGF and VEGF, among others. Results: The expression of VEGF resembled that of 'proliferating' hemangiomas; however, despite being markedly elevated in the urine, bFGF could not be unequivocally detected in the tumor. A subpopulation of factor XIIIa positive cells was identified, similar to the 'interstitial' cells of the cellular hemangiomas of infancy. The nature and function of these cells remains speculative. Conclusions: Hemangiopericytomas are rare in the liver. When arising in this location in a child, they may clinically resemble a hemangioma, may express angiogenic factors in a similar fashion, and should be considered in the differential diagnosis.
AB - Purpose: We describe an unusual case of a hemangiopericytoma in the liver of a child, review the literature, and characterize the tumor by immunohistochemistry and electron microscopy. We study the expression of basic fibroblast growth factor (bFGF) and of vascular endothelial growth factor (VEGF) in the tumor. Materials and Methods: Clinical history and pathology were reviewed; sections of the tumor were studied by histology, electron microscopy, and immunohistochemistry using antibodies directed towards Factor-XIIIa, HAM-56, bFGF and VEGF, among others. Results: The expression of VEGF resembled that of 'proliferating' hemangiomas; however, despite being markedly elevated in the urine, bFGF could not be unequivocally detected in the tumor. A subpopulation of factor XIIIa positive cells was identified, similar to the 'interstitial' cells of the cellular hemangiomas of infancy. The nature and function of these cells remains speculative. Conclusions: Hemangiopericytomas are rare in the liver. When arising in this location in a child, they may clinically resemble a hemangioma, may express angiogenic factors in a similar fashion, and should be considered in the differential diagnosis.
KW - Basic fibroblast growth factor
KW - Factor-XIIIa
KW - Hemangioma
KW - Hemangiopericytoma
KW - Vascular endothelial growth factor
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U2 - 10.1097/00043426-199709000-00008
DO - 10.1097/00043426-199709000-00008
M3 - Article
C2 - 9329468
AN - SCOPUS:0031414759
SN - 1077-4114
VL - 19
SP - 449
EP - 454
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
IS - 5
ER -