Hematogenous bacterial meningitis in an intercellular adhesion molecule-1-deficient infant mouse model

Tina Q. Tan, C. Wayne Smith, Edith P. Hawkins, Edward O. Mason, Sheldon L. Kaplan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Mice genetically deficient in the gene encoding for intercellular adhesion molecule-I (ICAMI) production were compared with wild-type mice after injection with Haemophilus injluenzae type b (Hib) or Streptococcus pneumoniae. The incidence of Hib bacteremia was greater in the ICAM-I-deficient mice than wild-type mice (P =.007), but mortality was greater for wild-type mice at 24 h (P =.03). In contrast, the incidence of S. pneumoniae bacteremia was equivalent but mortality was greater in ICAM-I-deficient mice at 24 h (P =.0003). More ICAM-I-deficient mice had cerebrospinal fluid cultures (CSF) positive for Hib (P =.04), whereas all animals at sacrifice had CSF cultures positive for S. pneumoniae. CSF white blood cell counts and histology of the meninges and cochlea were no different between groups for either organism. ICAM-l deficiency may be protective early in Hib infection but has a detrimental effect inS. pneumoniae infection.

Original languageEnglish (US)
Pages (from-to)342-349
Number of pages8
JournalJournal of Infectious Diseases
Volume171
Issue number2
DOIs
StatePublished - Feb 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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