Hematopoietic cell culture therapies (Part I): Cell culture considerations

Todd A. McAdams*, William M. Miller, E. Terry Papoutsakis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Hematopoietic cell culture, or ex vivo expansion of hematopoietic cells, is a rapidly growing area of tissue engineering with many potential applications in bone-marrow transplantation, gene therapy and the production of blood products. Hematopoietic cultures are considerably more complex than established animal cell culture technologies owing to the presence of many cell types at various differentiation stages, and stringent medium and growth factor requirements. Culture parameters, such as pH, oxygen tension, seeding density and feeding schedules, significantly affect the proliferation and differentiation of hematopoietic cells. A number of bioreactor systems are currently under development.

Original languageEnglish (US)
Pages (from-to)341-349
Number of pages9
JournalTrends in biotechnology
Issue number9
StatePublished - Sep 1996

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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