TY - JOUR
T1 - Hematopoietic cell culture therapies (Part II)
T2 - Clinical aspects and applications
AU - McAdams, Todd A.
AU - Winter, Jane N.
AU - Miller, William M.
AU - Papoutsakis, E. Terry
N1 - Funding Information:
Acknowledgement This work is supported by National Institutes of Health (USA) Grant ROl HL 48276. T. A. M. was partially supported by a Predoctoral Biotechn”ology Training Grant (NIH GM08449).
PY - 1996/10
Y1 - 1996/10
N2 - High-dose chemotherapy, followed by hematopoietic stem cell transplantation, holds significant promise for increasing the probability of long-term remission and possibly cure in a variety of cancers. Hematopoietic cell culture, or ex vivo expansion of hematopoietic cells, may play a significant role in reducing the danger and expense associated with the transplantation procedure. Phase I clinical trials have shown that ex vivo expanded cells have no significant toxicities, and some benefits. Ex vivo expansion of hematopoietic cells is likely to find other applications in gene therapy, tumor purging, production of dendritic cells for immunotherapy and the production of mature blood cells for transfusion therapies.
AB - High-dose chemotherapy, followed by hematopoietic stem cell transplantation, holds significant promise for increasing the probability of long-term remission and possibly cure in a variety of cancers. Hematopoietic cell culture, or ex vivo expansion of hematopoietic cells, may play a significant role in reducing the danger and expense associated with the transplantation procedure. Phase I clinical trials have shown that ex vivo expanded cells have no significant toxicities, and some benefits. Ex vivo expansion of hematopoietic cells is likely to find other applications in gene therapy, tumor purging, production of dendritic cells for immunotherapy and the production of mature blood cells for transfusion therapies.
UR - http://www.scopus.com/inward/record.url?scp=0013674429&partnerID=8YFLogxK
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U2 - 10.1016/0167-7799(96)10054-8
DO - 10.1016/0167-7799(96)10054-8
M3 - Review article
C2 - 8987637
AN - SCOPUS:0013674429
SN - 0167-7799
VL - 14
SP - 388
EP - 396
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 10
ER -
