Hematopoietic cell culture therapies (Part II): Clinical aspects and applications

Todd A. McAdams*, Jane N. Winter, William M. Miller, E. Terry Papoutsakis

*Corresponding author for this work

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

High-dose chemotherapy, followed by hematopoietic stem cell transplantation, holds significant promise for increasing the probability of long-term remission and possibly cure in a variety of cancers. Hematopoietic cell culture, or ex vivo expansion of hematopoietic cells, may play a significant role in reducing the danger and expense associated with the transplantation procedure. Phase I clinical trials have shown that ex vivo expanded cells have no significant toxicities, and some benefits. Ex vivo expansion of hematopoietic cells is likely to find other applications in gene therapy, tumor purging, production of dendritic cells for immunotherapy and the production of mature blood cells for transfusion therapies.

Original languageEnglish (US)
Pages (from-to)388-396
Number of pages9
JournalTrends in biotechnology
Volume14
Issue number10
DOIs
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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