Hematopoietic stem cell transplantation for severe rheumatoid arthritis

J. J. Moore*, J. Snowden, S. Pavletic, W. Barr, R. Burt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The substantial morbidity and mortality associated with rheumatoid arthritis (RA), while not widely appreciated, provide adequate justification for consideration of high-dose immunoablative therapy followed by hematopoietic stem cell transplantation. While some patients with RA follow a benign course, selected subsets of patients have been identified with 5-year survival rates of 40–70%. A number of factors that can be easily determined serve as useful prognostic indicators for poor outcome. These include the presence of many involved joints (total joint count), the degree of functional disability as measured by the health assessment questionnaire and the presence of rheumatoid factor. This article summarises the present status of hematopoietic stem cell transplantation for rheumatoid arthritis and proposes future directions for research.

Original languageEnglish (US)
Pages (from-to)S53-S56
JournalBone Marrow Transplantation
Volume32
DOIs
StatePublished - Aug 2003

Keywords

  • Hematopoietic stem cell transplantation
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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