Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: Is neoangiogenesis occurring?

R. K. Burt; Yu Oyama; A. Traynor; K. Quigley; M. Brush; J. Rodriguez; W. G. Barr

doi:10.1038/sj.bmt.1704055

Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: Is neoangiogenesis occurring?

R. K. Burt, Yu Oyama, A. Traynor, K. Quigley, M. Brush, J. Rodriguez, W. G. Barr

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Systemic sclerosis (SSc) is presumed to be an immune-mediated vasculopathy of unknown etiology. SSc is unresponsive to most immune-modulating therapies except for intravenous cyclophosphamide, which is reported to demonstrate some benefit. We, therefore, dose-escalated cyclophosphamide to 200 mg/kg and added rabbit ATG 7.5 mg/kg along with infusion of unselected hematopoietic stem cells to minimize the cytopenic interval. Engraftment occurred rapidly (day 8) with minimal unexpected toxicity, no infections, and unexpectedly rapid improvement in the modified Rodnan Skin Score.

Original language	English (US)
Pages (from-to)	S65-S67
Journal	Bone Marrow Transplantation
Volume	32
DOIs	https://doi.org/10.1038/sj.bmt.1704055
State	Published - 2003
Externally published	Yes

Keywords

Hematopoietic stem cell transplantation
Scleroderma

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1704055

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title = "Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: Is neoangiogenesis occurring?",

abstract = "Systemic sclerosis (SSc) is presumed to be an immune-mediated vasculopathy of unknown etiology. SSc is unresponsive to most immune-modulating therapies except for intravenous cyclophosphamide, which is reported to demonstrate some benefit. We, therefore, dose-escalated cyclophosphamide to 200 mg/kg and added rabbit ATG 7.5 mg/kg along with infusion of unselected hematopoietic stem cells to minimize the cytopenic interval. Engraftment occurred rapidly (day 8) with minimal unexpected toxicity, no infections, and unexpectedly rapid improvement in the modified Rodnan Skin Score.",

keywords = "Hematopoietic stem cell transplantation, Scleroderma",

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doi = "10.1038/sj.bmt.1704055",

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T1 - Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores

T2 - Is neoangiogenesis occurring?

AU - Burt, R. K.

AU - Oyama, Yu

AU - Traynor, A.

AU - Quigley, K.

AU - Brush, M.

AU - Rodriguez, J.

AU - Barr, W. G.

PY - 2003

Y1 - 2003

N2 - Systemic sclerosis (SSc) is presumed to be an immune-mediated vasculopathy of unknown etiology. SSc is unresponsive to most immune-modulating therapies except for intravenous cyclophosphamide, which is reported to demonstrate some benefit. We, therefore, dose-escalated cyclophosphamide to 200 mg/kg and added rabbit ATG 7.5 mg/kg along with infusion of unselected hematopoietic stem cells to minimize the cytopenic interval. Engraftment occurred rapidly (day 8) with minimal unexpected toxicity, no infections, and unexpectedly rapid improvement in the modified Rodnan Skin Score.

AB - Systemic sclerosis (SSc) is presumed to be an immune-mediated vasculopathy of unknown etiology. SSc is unresponsive to most immune-modulating therapies except for intravenous cyclophosphamide, which is reported to demonstrate some benefit. We, therefore, dose-escalated cyclophosphamide to 200 mg/kg and added rabbit ATG 7.5 mg/kg along with infusion of unselected hematopoietic stem cells to minimize the cytopenic interval. Engraftment occurred rapidly (day 8) with minimal unexpected toxicity, no infections, and unexpectedly rapid improvement in the modified Rodnan Skin Score.

KW - Hematopoietic stem cell transplantation

KW - Scleroderma

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JO - Bone Marrow Transplantation

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ER -

Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: Is neoangiogenesis occurring?

Abstract

Keywords

ASJC Scopus subject areas

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