TY - JOUR
T1 - Hemiallogeneic bone marrow transplantation in a child with severe combined immunodeficiency disease
AU - Frank Wu, Liang Yeh
AU - Rothberg, Richard M.
AU - Pachman, Lauren M.
AU - Coppleson, L. Warwick
AU - Larner, Bernard J.
AU - Peterson, Raymond D A
N1 - Funding Information:
Supported in part by United States Public Health Service Training Grant 5-TO1-AM-05539-03, United States Public Health Service Research Grant AI-07854, and General Clinical Research Centers Program Grant RR-305 \[rom the National Institutes o\[H ealth.
PY - 1972/3
Y1 - 1972/3
N2 - Immunologic reconstitution of a 16-month-old male infant with severe combined immunodeficiency disease was attempted using maternal bone marrow cells in the absence of an HL-A-identical donor. Following transplantation, lymphocytes from the recipient became responsive to phytohemagglutinin, Candida albicans, and type 12 M-protein from group A beta hemolytic streptococci. Karyotyping following phytohemagglutinin stimulation revealed that one fifth the responsive cells were of recipient origin (XY). Early signs of graft-versus-host reaction were noted by the fourteenth day. The involvement of skin, lungs, liver, and spleen became worse during the ensuing week, but by the twenty-first day, the patient's condition began to improve. The use of methotrexate, bowel sterilization, maternal plasma infusions, and other supportive measures were thought to be responsible for mitigating the graft-versus-host reaction. Despite substantial clearing of the involvement of the lungs, liver, and spleen, the patient died 41 days after transplantation.
AB - Immunologic reconstitution of a 16-month-old male infant with severe combined immunodeficiency disease was attempted using maternal bone marrow cells in the absence of an HL-A-identical donor. Following transplantation, lymphocytes from the recipient became responsive to phytohemagglutinin, Candida albicans, and type 12 M-protein from group A beta hemolytic streptococci. Karyotyping following phytohemagglutinin stimulation revealed that one fifth the responsive cells were of recipient origin (XY). Early signs of graft-versus-host reaction were noted by the fourteenth day. The involvement of skin, lungs, liver, and spleen became worse during the ensuing week, but by the twenty-first day, the patient's condition began to improve. The use of methotrexate, bowel sterilization, maternal plasma infusions, and other supportive measures were thought to be responsible for mitigating the graft-versus-host reaction. Despite substantial clearing of the involvement of the lungs, liver, and spleen, the patient died 41 days after transplantation.
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U2 - 10.1016/S0022-3476(72)80502-X
DO - 10.1016/S0022-3476(72)80502-X
M3 - Article
C2 - 4400714
AN - SCOPUS:0015304280
VL - 80
SP - 441
EP - 449
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 3
ER -