Hemiallogeneic bone marrow transplantation in a child with severe combined immunodeficiency disease

Liang Yeh Frank Wu, Richard M. Rothberg*, Lauren M. Pachman, L. Warwick Coppleson, Bernard J. Larner, Raymond D A Peterson

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Immunologic reconstitution of a 16-month-old male infant with severe combined immunodeficiency disease was attempted using maternal bone marrow cells in the absence of an HL-A-identical donor. Following transplantation, lymphocytes from the recipient became responsive to phytohemagglutinin, Candida albicans, and type 12 M-protein from group A beta hemolytic streptococci. Karyotyping following phytohemagglutinin stimulation revealed that one fifth the responsive cells were of recipient origin (XY). Early signs of graft-versus-host reaction were noted by the fourteenth day. The involvement of skin, lungs, liver, and spleen became worse during the ensuing week, but by the twenty-first day, the patient's condition began to improve. The use of methotrexate, bowel sterilization, maternal plasma infusions, and other supportive measures were thought to be responsible for mitigating the graft-versus-host reaction. Despite substantial clearing of the involvement of the lungs, liver, and spleen, the patient died 41 days after transplantation.

Original languageEnglish (US)
Pages (from-to)441-449
Number of pages9
JournalThe Journal of pediatrics
Volume80
Issue number3
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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