TY - JOUR
T1 - Hemicraniectomy in Traumatic Brain Injury
T2 - A Noninvasive Platform to Investigate High Gamma Activity for Brain Machine Interfaces
AU - Vaidya, Mukta
AU - Flint, Robert D.
AU - Wang, Po T.
AU - Barry, Alex
AU - Li, Yongcheng
AU - Ghassemi, Mohammad
AU - Tomic, Goran
AU - Yao, Jun
AU - Carmona, Carolina
AU - Mugler, Emily M.
AU - Gallick, Sarah
AU - Driver, Sangeeta
AU - Brkic, Nenad
AU - Ripley, David
AU - Liu, Charles
AU - Kamper, Derek
AU - Do, An H.
AU - Slutzky, Marc W.
N1 - Funding Information:
Manuscript received July 19, 2018; revised December 15, 2018 and January 9, 2019; accepted January 9, 2019. Date of publication April 23, 2019; date of current version July 4, 2019. This work was supported in part by the NIH Grant r01ns094748, and in part by the Doris Duke Charitable Foundation Clinical Scientist Development Award under Grant 2011039. (Corresponding author: Mukta Vaidya.) M. Vaidya, R. D. Flint, G. Tomic, and E. M. Mugler are with the Department of Neurology, Northwestern University, Chicago, IL 60611 USA (e-mail: mukta.vaidya@northwestern.edu; r-flint@northwestern.edu; goran.tomic@northwestern.edu; emilymugler@gmail.com).
PY - 2019/7
Y1 - 2019/7
N2 - Brain-machine interfaces (BMIs) translate brain signals into control signals for an external device, such as a computer cursor or robotic limb. These signals can be obtained either noninvasively or invasively. Invasive recordings, using electrocorticography (ECoG) or intracortical microelectrodes, provide higher bandwidth and more informative signals. Rehabilitative BMIs, which aim to drive plasticity in the brain to enhance recovery after brain injury, have almost exclusively used non-invasive recordings, such electroencephalography (EEG) or magnetoencephalography (MEG), which have limited bandwidth and information content. Invasive recordings provide more information and spatiotemporal resolution, but do incur risk, and thus are not usually investigated in people with stroke or traumatic brain injury (TBI). Here, in this paper, we describe a new BMI paradigm to investigate the use of higher frequency signals in brain-injured subjects without incurring significant risk. We recorded EEG in TBI subjects who required hemicraniectomies (removal of a part of the skull). EEG over the hemicraniectomy (hEEG) contained substantial information in the high gamma frequency range (65-115 Hz). Using this information, we decoded continuous finger flexion force with moderate to high accuracy (variance accounted for 0.06 to 0.52), which at best approaches that using epidural signals. These results indicate that people with hemicraniectomies can provide a useful resource for developing BMI therapies for the treatment of brain injury.
AB - Brain-machine interfaces (BMIs) translate brain signals into control signals for an external device, such as a computer cursor or robotic limb. These signals can be obtained either noninvasively or invasively. Invasive recordings, using electrocorticography (ECoG) or intracortical microelectrodes, provide higher bandwidth and more informative signals. Rehabilitative BMIs, which aim to drive plasticity in the brain to enhance recovery after brain injury, have almost exclusively used non-invasive recordings, such electroencephalography (EEG) or magnetoencephalography (MEG), which have limited bandwidth and information content. Invasive recordings provide more information and spatiotemporal resolution, but do incur risk, and thus are not usually investigated in people with stroke or traumatic brain injury (TBI). Here, in this paper, we describe a new BMI paradigm to investigate the use of higher frequency signals in brain-injured subjects without incurring significant risk. We recorded EEG in TBI subjects who required hemicraniectomies (removal of a part of the skull). EEG over the hemicraniectomy (hEEG) contained substantial information in the high gamma frequency range (65-115 Hz). Using this information, we decoded continuous finger flexion force with moderate to high accuracy (variance accounted for 0.06 to 0.52), which at best approaches that using epidural signals. These results indicate that people with hemicraniectomies can provide a useful resource for developing BMI therapies for the treatment of brain injury.
KW - Brain-machine interface
KW - EEG
KW - brain-computer interface
KW - high gamma
KW - traumatic brain injury
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U2 - 10.1109/TNSRE.2019.2912298
DO - 10.1109/TNSRE.2019.2912298
M3 - Article
C2 - 31021800
AN - SCOPUS:85068724450
VL - 27
SP - 1467
EP - 1472
JO - IEEE Transactions on Neural Systems and Rehabilitation Engineering
JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering
SN - 1534-4320
IS - 7
M1 - 8697146
ER -