Hemodynamic Changes Following Wingspan Stent Placement-A Quantitative Magnetic Resonance Angiography Study

Shyam Prabhakaran*, Kalani R. Wells, Miral D. Jhaveri, Demetrius K. Lopes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Quantitative magnetic resonance angiography (QMRA) is a noninvasive imaging modality that provides anatomic and physiologic measurements of arteries. We used QMRA to assess hemodynamic changes following Wingspan stent placement for intracranial stenosis. METHODS: We reviewed patients treated with Wingspan stents for intracranial stenosis who had baseline and follow-up QMRA data. We compared volumetric flow rates (VFRs) (mL/minute) pre- and poststenting using paired t-tests. P<.05 was considered significant. RESULTS: Among 9 patients (mean age 65.8 years, mean 71% degree of stenosis), lesions were located in the supraclinoid internal carotid arteries in 3, middle cerebral arteries in 3, and intracranial vertebrobasilar arteries in 3. VFR and degree of stenosis were moderately correlated (r=-.670, P=.002). The mean VFR in the stenotic artery increased from 81.2 mL/minute to 133.3 mL/minute (P=.020) or by 64.2% after stenting. Total cerebral blood flow, flow in nonstented vessels, and collateral flow in circle of Willis vessels did not significantly change. CONCLUSION: We found that QMRA is a promising noninvasive method for the measurement of cerebral hemodynamics following intracranial Wingspan stent placement. Larger prospective studies are needed to confirm our findings.

Original languageEnglish (US)
JournalJournal of Neuroimaging
Issue number2
StatePublished - Apr 1 2011


  • Cerebral blood flow
  • Intracranial stenosis
  • Noninvasive optimal vessel analysis (NOVA)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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