Hemodynamic effects of inhaled nitric oxide in four patients with severe liver disease and pulmonary hypertension

Andre M Dewolf*, V. Scott, R. Bjerke, Y. Kang, D. Kramer, A. Miro, J. J. Fung, F. Dodson, T. Gayowski, I. R. Marino, L. Firestone

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Patients with moderate and severe pulmonary hypertension have a very high mortality rate when undergoing orthotopic liver transplantation. Because nitric oxide has been successful in reducing pulmonary artery pressures in certain patients with pulmonary hypertension, the efficacy of NO inhalation (40 and 80 ppm) in 4 patients with pulmonary hypertension associated with liver disease was determined. No clinically significant changes in pulmonary artery pressures or other hemodynamic parameters were observed using either concentration of NO. In conclusion, no pulmonary vasodilatory response from inhalation of NO in 4 patients with severe liver disease and pulmonary hypertension was found.

Original languageEnglish (US)
Pages (from-to)594-597
Number of pages4
JournalLiver Transplantation and Surgery
Volume3
Issue number6
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Surgery
  • Hepatology

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    Dewolf, A. M., Scott, V., Bjerke, R., Kang, Y., Kramer, D., Miro, A., Fung, J. J., Dodson, F., Gayowski, T., Marino, I. R., & Firestone, L. (1997). Hemodynamic effects of inhaled nitric oxide in four patients with severe liver disease and pulmonary hypertension. Liver Transplantation and Surgery, 3(6), 594-597. https://doi.org/10.1002/lt.500030607