Hemodynamic effects of left atrial or left ventricular cannulation for acute circulatory support in a bovine model of left heart injury

Navin K. Kapur*, Vikram Paruchuri, Duc Thinh Pham, Lara Reyelt, Barbara Murphy, Corinna Beale, Courtney Bogins, Daniel Wiener, James Nilson, Michele Esposito, Scott Perkins, George Perides, Richard H. Karas

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Our objective was to examine the hemodynamic effects of a trans-aortic axial flow catheter (Impella CP) in the left ventricle (LV) versus left atrial (LA) to femoral artery bypass using a centrifugal pump (TandemHeart: TH) in a bovine model of acute LV injury. In three male calves, we performed sequential activation of a CP then TH device in each animal. After 60 minutes of left anterior descending artery ligation, a CP was activated at maximal power. The CP was then removed and the TH activated at 5,500 then a maximum of 7,500 rotations per minute (RPM). The CP generated a maximum 3.1 ± 0.2 L/minute (LPM) of flow, whereas the TH at 5,500 and 7,500 RPM generated 3.1 ± 0.4 and 4.4 ± 0.3 LPM. At 3.1 LPM, the CP and TH reduced LV stroke work (LVSW) similarly. The TH reduced stroke volume, whereas the CP did not. The CP reduced end-systolic pressure, whereas the TH did not. At a maximum flow of 4.4 LPM, the TH provided a greater reduction in LVSW than maximal CP activation. This is the first report to compare the hemodynamic effects of trans-aortic LV unloading versus LA-to-femoral artery (FA) bypass.

Original languageEnglish (US)
Pages (from-to)301-306
Number of pages6
JournalASAIO Journal
Volume61
Issue number3
DOIs
StatePublished - Jul 20 2015

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Keywords

  • circulatory support
  • heart failure
  • hemodynamics

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Kapur, N. K., Paruchuri, V., Pham, D. T., Reyelt, L., Murphy, B., Beale, C., Bogins, C., Wiener, D., Nilson, J., Esposito, M., Perkins, S., Perides, G., & Karas, R. H. (2015). Hemodynamic effects of left atrial or left ventricular cannulation for acute circulatory support in a bovine model of left heart injury. ASAIO Journal, 61(3), 301-306. https://doi.org/10.1097/MAT.0000000000000195