Patients with coronary artery disease often require a sedative drug while in the coronary care unit, preceding cardioversion, during pacemaker insertion and during cardiac catheterization. Diazepam has been used successfully at these times. Although this study shows that sedative doses of both drugs are safe to use in such patients, midazolam is preferable to diazepam because it is less irritating to veins and has a shorter duration of action. It is concluded that midazolam 0.05 mg/kg would be a safe sedative to use in patients with stable coronary artery disease and might be desirable as an intravenous sedative during cardiac catheterization because it does not alter hemodynamic measurements.
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine