Hemodynamic response of a canine model of chronic heart failure to intravenous dobutamine, nitroprusside, enalaprilat, and digoxin

Hani N. Sabbah*, T. Barry Levine, Mihai Gheorghiade, Tatsuji Kono, Sidney Goldstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The hemodynamic effects of acute intravenous administration of nitroprusside, dobutamine, enalaprilat, and digoxin was investigated in a canine model of chronic heart failure (CHF) produced by multiple sequential intracoronary microembolizations. Dobutamine (4 μg/kg/min) increased cardiac output (2.4±0.1 vs. 4.0±0.4 l/min; p<.001) and LV ejection fraction (LVEF; 26±1 vs. 30±4%; p<.01), and decreased systemic vascular resistance (SVR; 3620±170 vs. 2470±190 dynes sec cm-5; p<.001). Nitroprusside (3 μg/kg/min) acted as a venodilator; it decreased pulmonary artery wedge pressure (16±1 vs. 13±1 mmHg; p<.01) and SVR (3730±440 vs. 3210±280 dynes sec cm-5; NS) but had no effect on cardiac output. Enalaprilat (1.875 mg) produced a significant increase of cardiac output (3.0±0.5 vs. 3.8±0.5 l/min; p<.001) and LVEF (22±1 vs. 30±1%; p<.01), and decreased SVR (3280±400 vs. 2450±250 dynes sec cm-5; p<.01). Intravenous digoxin at a cumulative dose of 0.75 mg increased LVEF (23±2 vs. 31±2%; p<.01) but had no effect on SVR. These data indicate that this canine model of CHF responds to acute pharmacologic intervention in a manner comparable to that seen in patients with CHF. Accordingly, this model may be a useful tool for the preclinical evaluation of new drugs targeted toward the treatment of CHF and for investigating the mechanisms of action of drugs currently used for the treatment of this disease state.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalCardiovascular Drugs and Therapy
Volume7
Issue number3
DOIs
StatePublished - Jun 1 1993

Keywords

  • digoxin
  • dobutamine
  • enalaprilat
  • heart failure
  • nitroprusside

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Hemodynamic response of a canine model of chronic heart failure to intravenous dobutamine, nitroprusside, enalaprilat, and digoxin'. Together they form a unique fingerprint.

Cite this