Hemoglobin-based oxygen carriers for hemorrhagic shock

Jonathan Elmer*, Hasan B. Alam, Susan R. Wilcox

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Hemorrhagic shock is a pathologic state in which intravascular volume and tissue oxygen delivery are impaired, leading to circulatory collapse and cellular ischemia. Resuscitation with hemoglobin-based oxygen carriers (HBOCs) is appealing in that their use can both restore intravascular volume and tissue oxygenation, without the limitations in supply and immunomodulatory effects of packed red blood cells. However, the development of safe and effective agents has been elusive. In this article, we briefly discuss the major limitations of traditional resuscitative fluids which have driven the continued interest in HBOCs. We then review the history of early HBOC development and the modern understanding of their mechanisms of toxicity, which has informed the rational design of second-generation agents. Finally, we provide an overview of these second-generation HBOCs that are under active investigation or have recently completed phase 3 clinical trials.

Original languageEnglish (US)
Pages (from-to)285-292
Number of pages8
JournalResuscitation
Volume83
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • Blood alternatives
  • Hemoglobin-based oxygen carriers
  • Hemorrhagic shock
  • Transfusion

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

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