Abstract
The V protein of the recently emerged paramyxovirus, Nipah virus, has been shown to inhibit interferon (IFN) signal transduction through cytoplasmic sequestration of cellular STAT1 and STAT2 in high-molecular-weight complexes. Here we demonstrate that the closely related Hendra virus V protein also inhibits cellular responses to IFN through binding and cytoplasmic sequestration of both STAT1 and STAT2, but not STAT3. These findings demonstrate a V protein-mediated IFN signal evasion mechanism that is a general property of the known Henipavirus species.
Original language | English (US) |
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Pages (from-to) | 11842-11845 |
Number of pages | 4 |
Journal | Journal of virology |
Volume | 77 |
Issue number | 21 |
DOIs | |
State | Published - Nov 2003 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology