Heparin binding nanostructures to promote growth of blood vessels

Kanya Rajangam, Heather A. Behanna, Michael J. Hui, Xiaoqiang Han, James F. Hulvat, Jon W. Lomasney, Samuel I. Stupp*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

354 Scopus citations


Controlling new blood vessel formation is of interest in regenerative medicine and cancer treatment. Heparin, a biopolymer that binds to angiogenic growth factors, was used to nucleate the self-assembly of nanostructures from designed peptide amphiphile molecules. This process yields rigid nanofibers that display heparin chains to orient proteins for cell signaling. In vivo, the nanostructures stimulated extensive new blood vessel formation using nanogram amounts of growth-factor proteins that by themselves did not induce any detectable angiogenesis.

Original languageEnglish (US)
Pages (from-to)2086-2090
Number of pages5
JournalNano letters
Issue number9
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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