Heparin, klotho, and FGF23: the 3-beat waltz of the discordant heart

Marta Martinez-Calle; Valentin David

doi:10.1016/j.kint.2022.05.009

Heparin, klotho, and FGF23: the 3-beat waltz of the discordant heart

Marta Martinez-Calle, Valentin David^*

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

Excess fibroblast growth factor (FGF) 23 signaling in patients with chronic kidney disease induces left ventricular hypertrophy. In this issue, Yanucil et al. investigated the interaction of soluble klotho and heparin with FGF23 and FGF receptor isoforms. They concluded that heparin promotes the FGF23–FGF receptor isoform 4 interaction and FGF23 pathogenic effects, supporting an important role of heparin in the pathogenesis of FGF23-mediated left ventricular hypertrophy in chronic kidney disease.

Original language	English (US)
Pages (from-to)	228-230
Number of pages	3
Journal	Kidney international
Volume	102
Issue number	2
DOIs	https://doi.org/10.1016/j.kint.2022.05.009
State	Published - Aug 2022

Funding

VD received research funding from Akebia Therapeutics and Vifor Pharma and consulting honoraria from Keryx Biopharmaceuticals, Vifor Pharma, Luitpold, and Amgen (outside the submitted work). The other author declared no competing interests. VD was supported by grants from the National Institutes of Health (grant nos. R01DK102815 and R01DK114158).

ASJC Scopus subject areas

Nephrology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.kint.2022.05.009

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title = "Heparin, klotho, and FGF23: the 3-beat waltz of the discordant heart",

abstract = "Excess fibroblast growth factor (FGF) 23 signaling in patients with chronic kidney disease induces left ventricular hypertrophy. In this issue, Yanucil et al. investigated the interaction of soluble klotho and heparin with FGF23 and FGF receptor isoforms. They concluded that heparin promotes the FGF23–FGF receptor isoform 4 interaction and FGF23 pathogenic effects, supporting an important role of heparin in the pathogenesis of FGF23-mediated left ventricular hypertrophy in chronic kidney disease.",

author = "Marta Martinez-Calle and Valentin David",

note = "Publisher Copyright: {\textcopyright} 2022 International Society of Nephrology",

year = "2022",

month = aug,

doi = "10.1016/j.kint.2022.05.009",

language = "English (US)",

volume = "102",

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T1 - Heparin, klotho, and FGF23

T2 - the 3-beat waltz of the discordant heart

AU - Martinez-Calle, Marta

AU - David, Valentin

PY - 2022/8

Y1 - 2022/8

N2 - Excess fibroblast growth factor (FGF) 23 signaling in patients with chronic kidney disease induces left ventricular hypertrophy. In this issue, Yanucil et al. investigated the interaction of soluble klotho and heparin with FGF23 and FGF receptor isoforms. They concluded that heparin promotes the FGF23–FGF receptor isoform 4 interaction and FGF23 pathogenic effects, supporting an important role of heparin in the pathogenesis of FGF23-mediated left ventricular hypertrophy in chronic kidney disease.

AB - Excess fibroblast growth factor (FGF) 23 signaling in patients with chronic kidney disease induces left ventricular hypertrophy. In this issue, Yanucil et al. investigated the interaction of soluble klotho and heparin with FGF23 and FGF receptor isoforms. They concluded that heparin promotes the FGF23–FGF receptor isoform 4 interaction and FGF23 pathogenic effects, supporting an important role of heparin in the pathogenesis of FGF23-mediated left ventricular hypertrophy in chronic kidney disease.

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ER -

Heparin, klotho, and FGF23: the 3-beat waltz of the discordant heart

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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