Heparin-surface-modified intraocular lenses in pediatric cataract surgery: Prospective randomized study

Surendra Basti, Murali K. Aasuri*, Madhukar K. Reddy, Padmaja Preetam, Sreelakshmi Reddy, Satish Gupta, Thomas J. Naduvilath

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Purpose: To evaluate the performance of heparin-surface-modified (HSM) intraocular lenses (IOLs) in pediatric eyes after cataract surgery. Setting: L.V. Prasad Eye Institute, Hyderabad, India Methods: This prospective, randomizod, double-maske, controlled clinical trial com prised 90 children aged 2 to 14 years with cataract. The patients were consecutively randomized to receive an HSM (Group 1) or an unmodified (Group 2) poly(methyl methacrylate) (PMMA) IOL. Extracapsular cataract extraction (ECCE) with IOL implan- tation was performed in children 8 years and older and ECCE with primary posterior capsulotomy, anterior vitrectomy, and IOL implantation in children younger than 8 years. Outcome parameters were inflammatory cell deposits on the IOL surface, posterior synechlas and anterior chamber reaction. Results: Follow-up data were available for 73, 70, 60, and 68 patients at 1 week, 1 month, 3 months, and 6 months, respectively, Significantly fewer cell deposits were noted in Group 1 at 1, 3, and 6 months (P < .001). Synechia formation and anterior chamber reaction were compaarable in the 2 groups Conclusion: The lower incidence of inflammatory cell deposit formation in eyes with HSM PMMA IOLs indicates that these IOLs have greater bicompatibility than unmodified IOLs in pediatric cataract surgery.

Original languageEnglish (US)
Pages (from-to)782-787
Number of pages6
JournalJournal of cataract and refractive surgery
Issue number6
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology
  • Sensory Systems


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