TY - JOUR
T1 - Heparin-surface-modified intraocular lenses in pediatric cataract surgery
T2 - Prospective randomized study
AU - Basti, Surendra
AU - Aasuri, Murali K.
AU - Reddy, Madhukar K.
AU - Preetam, Padmaja
AU - Reddy, Sreelakshmi
AU - Gupta, Satish
AU - Naduvilath, Thomas J.
N1 - Funding Information:
Supported in part by the Hyderabad Eye Research Foundation, Hyderabad, and Pharmacia & Upjohn India, Bangalore, India.
PY - 1999/6
Y1 - 1999/6
N2 - Purpose: To evaluate the performance of heparin-surface-modified (HSM) intraocular lenses (IOLs) in pediatric eyes after cataract surgery. Setting: L.V. Prasad Eye Institute, Hyderabad, India Methods: This prospective, randomizod, double-maske, controlled clinical trial com prised 90 children aged 2 to 14 years with cataract. The patients were consecutively randomized to receive an HSM (Group 1) or an unmodified (Group 2) poly(methyl methacrylate) (PMMA) IOL. Extracapsular cataract extraction (ECCE) with IOL implan- tation was performed in children 8 years and older and ECCE with primary posterior capsulotomy, anterior vitrectomy, and IOL implantation in children younger than 8 years. Outcome parameters were inflammatory cell deposits on the IOL surface, posterior synechlas and anterior chamber reaction. Results: Follow-up data were available for 73, 70, 60, and 68 patients at 1 week, 1 month, 3 months, and 6 months, respectively, Significantly fewer cell deposits were noted in Group 1 at 1, 3, and 6 months (P < .001). Synechia formation and anterior chamber reaction were compaarable in the 2 groups Conclusion: The lower incidence of inflammatory cell deposit formation in eyes with HSM PMMA IOLs indicates that these IOLs have greater bicompatibility than unmodified IOLs in pediatric cataract surgery.
AB - Purpose: To evaluate the performance of heparin-surface-modified (HSM) intraocular lenses (IOLs) in pediatric eyes after cataract surgery. Setting: L.V. Prasad Eye Institute, Hyderabad, India Methods: This prospective, randomizod, double-maske, controlled clinical trial com prised 90 children aged 2 to 14 years with cataract. The patients were consecutively randomized to receive an HSM (Group 1) or an unmodified (Group 2) poly(methyl methacrylate) (PMMA) IOL. Extracapsular cataract extraction (ECCE) with IOL implan- tation was performed in children 8 years and older and ECCE with primary posterior capsulotomy, anterior vitrectomy, and IOL implantation in children younger than 8 years. Outcome parameters were inflammatory cell deposits on the IOL surface, posterior synechlas and anterior chamber reaction. Results: Follow-up data were available for 73, 70, 60, and 68 patients at 1 week, 1 month, 3 months, and 6 months, respectively, Significantly fewer cell deposits were noted in Group 1 at 1, 3, and 6 months (P < .001). Synechia formation and anterior chamber reaction were compaarable in the 2 groups Conclusion: The lower incidence of inflammatory cell deposit formation in eyes with HSM PMMA IOLs indicates that these IOLs have greater bicompatibility than unmodified IOLs in pediatric cataract surgery.
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U2 - 10.1016/S0886-3350(99)00039-5
DO - 10.1016/S0886-3350(99)00039-5
M3 - Article
C2 - 10374157
AN - SCOPUS:0032978398
SN - 0886-3350
VL - 25
SP - 782
EP - 787
JO - Journal of cataract and refractive surgery
JF - Journal of cataract and refractive surgery
IS - 6
ER -