Hepatic clearance of chylomicron remnants m mice lacking apoprotein E

Suyi Chang, Sunny H. Zhang, Nobuyo Maeda, Jayme Borensztajn*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Control and apoprotein E-deficient mice generated by gene targeting in embryonic stem cells were fed a fat load containing 3H-labeled retinol and the absorbed radioactivity present in the plasma, liver, and carcass measured 6 h later. The radioactivity in the plasma of the apoprotein E-deficient mice was several fold higher than in control animals, but it accounted for less than 1 5 of the absorbed radioactivity. In both groups of animals most of the absorbed radioactivity was recovered in the livers. These findings indicate that in apoprotein E-deficient mice chylomicron remnants can be taken up by the liver by a process that does not require the mediation of apoprotein E.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume1215
Issue number1-2
DOIs
StatePublished - Nov 17 1994

Keywords

  • (Mouse)
  • Apoprotein E
  • Chilomicron
  • Chilomicron remnant removal
  • Hepatic uptake
  • Lipoprotein

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

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