Hepatic radiofrequency ablation with internally cooled probes: Effect of coolant temperature on lesion size

Dieter Haemmerich, Louay Chachati, Andrew S. Wright, David M. Mahvi, Fred T. Lee, John G. Webster*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

Radiofrequency (RF) ablation is a minimally invasive method for treatment of primary and metastatic liver tumors. One of the currently commercially available devices employs an internally cooled 17-gauge needle probe. Within the probe, cool water is circulated during ablation, which cools tissue close to the probe resulting in larger lesions. We evaluated the effect of different cooling water temperatures on lesion size. We created a finite-element method model, simulated 12 min impedance-controlled ablation and determined temperature distribution for three water temperatures. Lesion diameters in the model were 33.8, 33.4, and 32.8 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. We solved a simplified model geometry analytically and present dependence of lesion diameter on cooling temperature. We further performed ex vivo experiments in fresh bovine liver. We created four lesions for each water temperature, with the same water temperatures as used in the finite-element method (FEM) model. Average lesion diameters were 28.3, 30, and 29.5 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. Water temperature did not have a significant effect on lesion size in the ex vivo experiments (p = 0.76), the FEM model, and the analytical solution.

Original languageEnglish (US)
Pages (from-to)493-500
Number of pages8
JournalIEEE Transactions on Biomedical Engineering
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2003

Keywords

  • Ablation
  • Bipolar ablation
  • Finite-element method
  • Hepatic ablation
  • Liver ablation
  • Multiprobe
  • RF ablation
  • RFA
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Biomedical Engineering

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