Hepatic radiofrequency ablation with internally cooled probes: Effect of coolant temperature on lesion size

Dieter Haemmerich; Louay Chachati; Andrew S. Wright; David M. Mahvi; Fred T. Lee; John G. Webster

doi:10.1109/TBME.2003.809488

Hepatic radiofrequency ablation with internally cooled probes: Effect of coolant temperature on lesion size

Dieter Haemmerich, Louay Chachati, Andrew S. Wright, David M. Mahvi, Fred T. Lee, John G. Webster^*

^*Corresponding author for this work

Surgery, Surgical Oncology Division

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

Radiofrequency (RF) ablation is a minimally invasive method for treatment of primary and metastatic liver tumors. One of the currently commercially available devices employs an internally cooled 17-gauge needle probe. Within the probe, cool water is circulated during ablation, which cools tissue close to the probe resulting in larger lesions. We evaluated the effect of different cooling water temperatures on lesion size. We created a finite-element method model, simulated 12 min impedance-controlled ablation and determined temperature distribution for three water temperatures. Lesion diameters in the model were 33.8, 33.4, and 32.8 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. We solved a simplified model geometry analytically and present dependence of lesion diameter on cooling temperature. We further performed ex vivo experiments in fresh bovine liver. We created four lesions for each water temperature, with the same water temperatures as used in the finite-element method (FEM) model. Average lesion diameters were 28.3, 30, and 29.5 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. Water temperature did not have a significant effect on lesion size in the ex vivo experiments (p = 0.76), the FEM model, and the analytical solution.

Original language	English (US)
Pages (from-to)	493-500
Number of pages	8
Journal	IEEE Transactions on Biomedical Engineering
Volume	50
Issue number	4
DOIs	https://doi.org/10.1109/TBME.2003.809488
State	Published - Apr 1 2003

Funding

Manuscript received August 5, 2002; revised November 22, 2002. This work was supported by the National Institute of Health (NIH) under Grants HL56413 and DK58839. Asterisk indicates corresponding author. D. Haemmerich, A. S. Wright, and D. M. Mahvi are with the Department of Surgery, University of Wisconsin, Madison, WI 53792 USA. L. Chachati is with the Department of Electrical & Electronics Engineering, University of Aleppo, Aleppo, Syria. F. T. Lee, Jr. is with the Department of Radiology, University of Wisconsin, Madison, WI 53792 USA. *J. G. Webster is with the Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706 USA (e-mail: [email protected]). Digital Object Identifier 10.1109/TBME.2003.809488

Keywords

Ablation
Bipolar ablation
Finite-element method
Hepatic ablation
Liver ablation
Multiprobe
RF ablation
RFA
Radiofrequency ablation

ASJC Scopus subject areas

Biomedical Engineering

Access to Document

10.1109/TBME.2003.809488

Cite this

@article{434e1732680e442aa65f0648eb6117e9,

title = "Hepatic radiofrequency ablation with internally cooled probes: Effect of coolant temperature on lesion size",

abstract = "Radiofrequency (RF) ablation is a minimally invasive method for treatment of primary and metastatic liver tumors. One of the currently commercially available devices employs an internally cooled 17-gauge needle probe. Within the probe, cool water is circulated during ablation, which cools tissue close to the probe resulting in larger lesions. We evaluated the effect of different cooling water temperatures on lesion size. We created a finite-element method model, simulated 12 min impedance-controlled ablation and determined temperature distribution for three water temperatures. Lesion diameters in the model were 33.8, 33.4, and 32.8 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. We solved a simplified model geometry analytically and present dependence of lesion diameter on cooling temperature. We further performed ex vivo experiments in fresh bovine liver. We created four lesions for each water temperature, with the same water temperatures as used in the finite-element method (FEM) model. Average lesion diameters were 28.3, 30, and 29.5 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. Water temperature did not have a significant effect on lesion size in the ex vivo experiments (p = 0.76), the FEM model, and the analytical solution.",

keywords = "Ablation, Bipolar ablation, Finite-element method, Hepatic ablation, Liver ablation, Multiprobe, RF ablation, RFA, Radiofrequency ablation",

author = "Dieter Haemmerich and Louay Chachati and Wright, {Andrew S.} and Mahvi, {David M.} and Lee, {Fred T.} and Webster, {John G.}",

note = "Funding Information: Manuscript received August 5, 2002; revised November 22, 2002. This work was supported by the National Institute of Health (NIH) under Grants HL56413 and DK58839. Asterisk indicates corresponding author. D. Haemmerich, A. S. Wright, and D. M. Mahvi are with the Department of Surgery, University of Wisconsin, Madison, WI 53792 USA. L. Chachati is with the Department of Electrical & Electronics Engineering, University of Aleppo, Aleppo, Syria. F. T. Lee, Jr. is with the Department of Radiology, University of Wisconsin, Madison, WI 53792 USA. *J. G. Webster is with the Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706 USA (e-mail: [email protected]). Digital Object Identifier 10.1109/TBME.2003.809488",

year = "2003",

month = apr,

day = "1",

doi = "10.1109/TBME.2003.809488",

language = "English (US)",

volume = "50",

pages = "493--500",

journal = "IEEE Transactions on Biomedical Engineering",

issn = "0018-9294",

publisher = "IEEE Computer Society",

number = "4",

}

TY - JOUR

T1 - Hepatic radiofrequency ablation with internally cooled probes

T2 - Effect of coolant temperature on lesion size

AU - Haemmerich, Dieter

AU - Chachati, Louay

AU - Wright, Andrew S.

AU - Mahvi, David M.

AU - Lee, Fred T.

AU - Webster, John G.

N1 - Funding Information: Manuscript received August 5, 2002; revised November 22, 2002. This work was supported by the National Institute of Health (NIH) under Grants HL56413 and DK58839. Asterisk indicates corresponding author. D. Haemmerich, A. S. Wright, and D. M. Mahvi are with the Department of Surgery, University of Wisconsin, Madison, WI 53792 USA. L. Chachati is with the Department of Electrical & Electronics Engineering, University of Aleppo, Aleppo, Syria. F. T. Lee, Jr. is with the Department of Radiology, University of Wisconsin, Madison, WI 53792 USA. *J. G. Webster is with the Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, WI 53706 USA (e-mail: [email protected]). Digital Object Identifier 10.1109/TBME.2003.809488

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Radiofrequency (RF) ablation is a minimally invasive method for treatment of primary and metastatic liver tumors. One of the currently commercially available devices employs an internally cooled 17-gauge needle probe. Within the probe, cool water is circulated during ablation, which cools tissue close to the probe resulting in larger lesions. We evaluated the effect of different cooling water temperatures on lesion size. We created a finite-element method model, simulated 12 min impedance-controlled ablation and determined temperature distribution for three water temperatures. Lesion diameters in the model were 33.8, 33.4, and 32.8 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. We solved a simplified model geometry analytically and present dependence of lesion diameter on cooling temperature. We further performed ex vivo experiments in fresh bovine liver. We created four lesions for each water temperature, with the same water temperatures as used in the finite-element method (FEM) model. Average lesion diameters were 28.3, 30, and 29.5 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. Water temperature did not have a significant effect on lesion size in the ex vivo experiments (p = 0.76), the FEM model, and the analytical solution.

AB - Radiofrequency (RF) ablation is a minimally invasive method for treatment of primary and metastatic liver tumors. One of the currently commercially available devices employs an internally cooled 17-gauge needle probe. Within the probe, cool water is circulated during ablation, which cools tissue close to the probe resulting in larger lesions. We evaluated the effect of different cooling water temperatures on lesion size. We created a finite-element method model, simulated 12 min impedance-controlled ablation and determined temperature distribution for three water temperatures. Lesion diameters in the model were 33.8, 33.4, and 32.8 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. We solved a simplified model geometry analytically and present dependence of lesion diameter on cooling temperature. We further performed ex vivo experiments in fresh bovine liver. We created four lesions for each water temperature, with the same water temperatures as used in the finite-element method (FEM) model. Average lesion diameters were 28.3, 30, and 29.5 mm for water temperatures of 5 °C, 15 °C, and 25 °C, respectively. Water temperature did not have a significant effect on lesion size in the ex vivo experiments (p = 0.76), the FEM model, and the analytical solution.

KW - Ablation

KW - Bipolar ablation

KW - Finite-element method

KW - Hepatic ablation

KW - Liver ablation

KW - Multiprobe

KW - RF ablation

KW - RFA

KW - Radiofrequency ablation

UR - http://www.scopus.com/inward/record.url?scp=0242380338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242380338&partnerID=8YFLogxK

U2 - 10.1109/TBME.2003.809488

DO - 10.1109/TBME.2003.809488

M3 - Article

C2 - 12723061

AN - SCOPUS:0242380338

SN - 0018-9294

VL - 50

SP - 493

EP - 500

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

IS - 4

ER -

Hepatic radiofrequency ablation with internally cooled probes: Effect of coolant temperature on lesion size

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this