Hepatitis B and C Virus Co-Infection and Their Association With Liver Disease in Persons With HIV in Nigeria

Emuobor Odeghe; Ganiyat Oyeleke; Mayowa Odofin; Mary Duguru; Pantong Davwar; David Nyam; Olufunmilayo Lesi; Edith Okeke; Hameed Adelabu; Oluwakemi Odukoya; Alani Akanmu; Wasiu Adeyemo; Fatimah Abdulkareem; Godwin Imade; Brian Joyce; Imran Khan; Ariel Chandler; Atiene Sagay; Robert Murphy; Lifang Hou; Claudia Hawkins

doi:10.1177/23259582241292511

Hepatitis B and C Virus Co-Infection and Their Association With Liver Disease in Persons With HIV in Nigeria

Emuobor Odeghe^*, Ganiyat Oyeleke, Mayowa Odofin, Mary Duguru, Pantong Davwar, David Nyam, Olufunmilayo Lesi, Edith Okeke, Hameed Adelabu, Oluwakemi Odukoya, Alani Akanmu, Wasiu Adeyemo, Fatimah Abdulkareem, Godwin Imade, Brian Joyce, Imran Khan, Ariel Chandler, Atiene Sagay, Robert Murphy, Lifang HouClaudia Hawkins

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The burden of chronic viral hepatitis among people living with human immunodeficiency virus (PLWH) and its association with liver disease in Nigeria has been seldom explored. Our objective was to compare characteristics in PLWH with and without significant liver fibrosis/cirrhosis, examining its association with viral hepatitis and other risk factors. Methods: Cross-sectional study among PLWH with and without significant fibrosis/cirrhosis (transient elastography ≥ 9.3 kPa) between July 2018 and August 2022. Data were compared between participant groups and logistic regression used to determine association between chronic viral hepatitis and significant fibrosis/cirrhosis. Results: Five hundred and thirty-seven participants (34.3% male), median age 46 years, 22.2% with significant fibrosis/cirrhosis were analyzed. Seroprevalence of hepatitis B virus (HBV) was 11.2% and hepatitis C virus (HCV) 5.7%. Male sex, diabetes, HBV, and HCV were associated with significant fibrosis/cirrhosis, while ART for >5 years was associated with reduced risk. Conclusion: The chronic hepatitis viruses are associated with significant liver fibrosis/cirrhosis in PLWH in Nigeria, highlighting the importance of viral hepatitis awareness, screening, and treatment in HIV programs to reduce the risk of liver disease. Plain Language Summary: Hepatitis B and C infection and liver disease in people with HIV infection in Nigeria People living with human immunodeficiency virus (HIV) infection who have hepatitis B or C infection have a higher chance of developing advanced liver disease than those who do not have either of the hepatitis infections. This finding highlights the importance of awareness, screening, and treatment of the hepatitis viruses in HIV programs in order to reduce the risk of liver disease in this population.

Original language	English (US)
Journal	Journal of the International Association of Providers of AIDS Care
Volume	23
DOIs	https://doi.org/10.1177/23259582241292511
State	Published - Jan 1 2024

Funding

We thank Professor Folasade Ogunsola for her contributions to this work. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the Division of Cancer Prevention, National Cancer Institute, grant no.: NIH/NCI U54CA221205 (PI Robert Murphy, Lifang Hou).

Keywords

HBV
HCV
HIV
Nigeria
fibroscan
liver disease
liver fibrosis

ASJC Scopus subject areas

Immunology
Dermatology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1177/23259582241292511

Cite this

Odeghe, E., Oyeleke, G., Odofin, M., Duguru, M., Davwar, P., Nyam, D., Lesi, O., Okeke, E., Adelabu, H., Odukoya, O., Akanmu, A., Adeyemo, W., Abdulkareem, F., Imade, G., Joyce, B., Khan, I., Chandler, A., Sagay, A., Murphy, R., ... Hawkins, C. (2024). Hepatitis B and C Virus Co-Infection and Their Association With Liver Disease in Persons With HIV in Nigeria. Journal of the International Association of Providers of AIDS Care, 23. https://doi.org/10.1177/23259582241292511

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title = "Hepatitis B and C Virus Co-Infection and Their Association With Liver Disease in Persons With HIV in Nigeria",

abstract = "Background: The burden of chronic viral hepatitis among people living with human immunodeficiency virus (PLWH) and its association with liver disease in Nigeria has been seldom explored. Our objective was to compare characteristics in PLWH with and without significant liver fibrosis/cirrhosis, examining its association with viral hepatitis and other risk factors. Methods: Cross-sectional study among PLWH with and without significant fibrosis/cirrhosis (transient elastography ≥ 9.3 kPa) between July 2018 and August 2022. Data were compared between participant groups and logistic regression used to determine association between chronic viral hepatitis and significant fibrosis/cirrhosis. Results: Five hundred and thirty-seven participants (34.3% male), median age 46 years, 22.2% with significant fibrosis/cirrhosis were analyzed. Seroprevalence of hepatitis B virus (HBV) was 11.2% and hepatitis C virus (HCV) 5.7%. Male sex, diabetes, HBV, and HCV were associated with significant fibrosis/cirrhosis, while ART for >5 years was associated with reduced risk. Conclusion: The chronic hepatitis viruses are associated with significant liver fibrosis/cirrhosis in PLWH in Nigeria, highlighting the importance of viral hepatitis awareness, screening, and treatment in HIV programs to reduce the risk of liver disease. Plain Language Summary: Hepatitis B and C infection and liver disease in people with HIV infection in Nigeria People living with human immunodeficiency virus (HIV) infection who have hepatitis B or C infection have a higher chance of developing advanced liver disease than those who do not have either of the hepatitis infections. This finding highlights the importance of awareness, screening, and treatment of the hepatitis viruses in HIV programs in order to reduce the risk of liver disease in this population.",

keywords = "HBV, HCV, HIV, Nigeria, fibroscan, liver disease, liver fibrosis",

author = "Emuobor Odeghe and Ganiyat Oyeleke and Mayowa Odofin and Mary Duguru and Pantong Davwar and David Nyam and Olufunmilayo Lesi and Edith Okeke and Hameed Adelabu and Oluwakemi Odukoya and Alani Akanmu and Wasiu Adeyemo and Fatimah Abdulkareem and Godwin Imade and Brian Joyce and Imran Khan and Ariel Chandler and Atiene Sagay and Robert Murphy and Lifang Hou and Claudia Hawkins",

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language = "English (US)",

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Odeghe, E, Oyeleke, G, Odofin, M, Duguru, M, Davwar, P, Nyam, D, Lesi, O, Okeke, E, Adelabu, H, Odukoya, O, Akanmu, A, Adeyemo, W, Abdulkareem, F, Imade, G, Joyce, B, Khan, I, Chandler, A, Sagay, A, Murphy, R , Hou, L & Hawkins, C 2024, 'Hepatitis B and C Virus Co-Infection and Their Association With Liver Disease in Persons With HIV in Nigeria', Journal of the International Association of Providers of AIDS Care, vol. 23. https://doi.org/10.1177/23259582241292511

TY - JOUR

T1 - Hepatitis B and C Virus Co-Infection and Their Association With Liver Disease in Persons With HIV in Nigeria

AU - Odeghe, Emuobor

AU - Oyeleke, Ganiyat

AU - Odofin, Mayowa

AU - Duguru, Mary

AU - Davwar, Pantong

AU - Nyam, David

AU - Lesi, Olufunmilayo

AU - Okeke, Edith

AU - Adelabu, Hameed

AU - Odukoya, Oluwakemi

AU - Akanmu, Alani

AU - Adeyemo, Wasiu

AU - Abdulkareem, Fatimah

AU - Imade, Godwin

AU - Joyce, Brian

AU - Khan, Imran

AU - Chandler, Ariel

AU - Sagay, Atiene

AU - Murphy, Robert

AU - Hou, Lifang

AU - Hawkins, Claudia

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Background: The burden of chronic viral hepatitis among people living with human immunodeficiency virus (PLWH) and its association with liver disease in Nigeria has been seldom explored. Our objective was to compare characteristics in PLWH with and without significant liver fibrosis/cirrhosis, examining its association with viral hepatitis and other risk factors. Methods: Cross-sectional study among PLWH with and without significant fibrosis/cirrhosis (transient elastography ≥ 9.3 kPa) between July 2018 and August 2022. Data were compared between participant groups and logistic regression used to determine association between chronic viral hepatitis and significant fibrosis/cirrhosis. Results: Five hundred and thirty-seven participants (34.3% male), median age 46 years, 22.2% with significant fibrosis/cirrhosis were analyzed. Seroprevalence of hepatitis B virus (HBV) was 11.2% and hepatitis C virus (HCV) 5.7%. Male sex, diabetes, HBV, and HCV were associated with significant fibrosis/cirrhosis, while ART for >5 years was associated with reduced risk. Conclusion: The chronic hepatitis viruses are associated with significant liver fibrosis/cirrhosis in PLWH in Nigeria, highlighting the importance of viral hepatitis awareness, screening, and treatment in HIV programs to reduce the risk of liver disease. Plain Language Summary: Hepatitis B and C infection and liver disease in people with HIV infection in Nigeria People living with human immunodeficiency virus (HIV) infection who have hepatitis B or C infection have a higher chance of developing advanced liver disease than those who do not have either of the hepatitis infections. This finding highlights the importance of awareness, screening, and treatment of the hepatitis viruses in HIV programs in order to reduce the risk of liver disease in this population.

AB - Background: The burden of chronic viral hepatitis among people living with human immunodeficiency virus (PLWH) and its association with liver disease in Nigeria has been seldom explored. Our objective was to compare characteristics in PLWH with and without significant liver fibrosis/cirrhosis, examining its association with viral hepatitis and other risk factors. Methods: Cross-sectional study among PLWH with and without significant fibrosis/cirrhosis (transient elastography ≥ 9.3 kPa) between July 2018 and August 2022. Data were compared between participant groups and logistic regression used to determine association between chronic viral hepatitis and significant fibrosis/cirrhosis. Results: Five hundred and thirty-seven participants (34.3% male), median age 46 years, 22.2% with significant fibrosis/cirrhosis were analyzed. Seroprevalence of hepatitis B virus (HBV) was 11.2% and hepatitis C virus (HCV) 5.7%. Male sex, diabetes, HBV, and HCV were associated with significant fibrosis/cirrhosis, while ART for >5 years was associated with reduced risk. Conclusion: The chronic hepatitis viruses are associated with significant liver fibrosis/cirrhosis in PLWH in Nigeria, highlighting the importance of viral hepatitis awareness, screening, and treatment in HIV programs to reduce the risk of liver disease. Plain Language Summary: Hepatitis B and C infection and liver disease in people with HIV infection in Nigeria People living with human immunodeficiency virus (HIV) infection who have hepatitis B or C infection have a higher chance of developing advanced liver disease than those who do not have either of the hepatitis infections. This finding highlights the importance of awareness, screening, and treatment of the hepatitis viruses in HIV programs in order to reduce the risk of liver disease in this population.

KW - HBV

KW - HCV

KW - HIV

KW - Nigeria

KW - fibroscan

KW - liver disease

KW - liver fibrosis

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U2 - 10.1177/23259582241292511

DO - 10.1177/23259582241292511

M3 - Article

C2 - 39469965

AN - SCOPUS:85208082143

SN - 2325-9574

VL - 23

JO - Journal of the International Association of Providers of AIDS Care

JF - Journal of the International Association of Providers of AIDS Care

ER -

Hepatitis B and C Virus Co-Infection and Their Association With Liver Disease in Persons With HIV in Nigeria

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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