TY - JOUR
T1 - Hepatitis B reactivation in patients with multiple myeloma and isolated positive hepatitis B core antibody
T2 - A call for greater cognizance
AU - Yang, Ju Dong
AU - Girotra, Mohit
AU - Restrepo, Alejandro
AU - Waheed, Sarah
AU - Barlogie, Bart
AU - Duarte-Rojo, Andres
PY - 2014
Y1 - 2014
N2 - Hepatitis B virus (HBV) reactivation is a well-established complication of severe immunosuppression in patients with hematologic malignancy and positive hepatitis B surface antigen (HBsAg). Patients who receive high-dose chemotherapy, corticosteroids, rituximab, or have a bone marrow transplant are particularly at increased risk for HBV reactivation. However, limited information is available in the literature regarding HBV reactivation in patients with isolated anti-HBc, particularly in the setting of multiple myeloma (MM). We report two cases of HBV reactivation in MM patients with isolated anti-HBc positive with a rather atypical presentation. In conclusion, our cases highlight that clinicians need to be cognizant about this potentially fatal but preventable complication of chemotherapy and immunosuppression.
AB - Hepatitis B virus (HBV) reactivation is a well-established complication of severe immunosuppression in patients with hematologic malignancy and positive hepatitis B surface antigen (HBsAg). Patients who receive high-dose chemotherapy, corticosteroids, rituximab, or have a bone marrow transplant are particularly at increased risk for HBV reactivation. However, limited information is available in the literature regarding HBV reactivation in patients with isolated anti-HBc, particularly in the setting of multiple myeloma (MM). We report two cases of HBV reactivation in MM patients with isolated anti-HBc positive with a rather atypical presentation. In conclusion, our cases highlight that clinicians need to be cognizant about this potentially fatal but preventable complication of chemotherapy and immunosuppression.
KW - Bone marrow transplant
KW - Chemotherapy
KW - Hematologic malignancy
KW - Viral hepatitis
UR - http://www.scopus.com/inward/record.url?scp=84902386802&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902386802&partnerID=8YFLogxK
U2 - 10.1016/s1665-2681(19)30855-5
DO - 10.1016/s1665-2681(19)30855-5
M3 - Article
C2 - 24927619
AN - SCOPUS:84902386802
SN - 1665-2681
VL - 13
SP - 461
EP - 465
JO - Annals of Hepatology
JF - Annals of Hepatology
IS - 4
ER -
