Hepatitis C in liver transplantation: preliminary study of prognostic factors

J. Nery*, V. Esquenazi, D. Weppler, C. Gomez, R. Cirocco, H. Gharagozloo, K. Zucker, J. Casella, W. Faria, M. Carreno, J. Smith, M. Markow, M. Allouch, S. Babischkin, G. Bourke, Joshua Miller, R. Reddy, T. Parker, L. Jeffers, M. HillS. LaRue, E. Schiff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Abstract At the University of Miami liver transplantation for chronic liver disease in HCV‐positive patients has shown good results, with a 92% patients survival rate (follow up 8 to 57 months, median 21). None the less, we found that a large number of patients are expected to develop serious histological graft damage and may need retransplantation, which may place a further strain on the already scarce donor resources. We have conducted a preliminary investigation on the importance of parameters which may correlate with the prognosis of HCV grafts. We found no impact of HLA match or typing. An interesting hypothesis, which deserves further investigation, is that some HCV strains could be more virulent than others and play a role as an independent risk factor. We have identified six strains among our patients and the BK serotype shows a trend to be associated with a worse outcome. We have found that patients developing and maintaining higher liver enzyme levels (ALT and GGT) after transplant and those with higher levels of viremia may be at risk to develop serious damage to their grafts.

Original languageEnglish (US)
Pages (from-to)229-231
Number of pages3
JournalTransplant International
Volume7
DOIs
StatePublished - Dec 1994

Keywords

  • Hepatitis C
  • Liver transplantation

ASJC Scopus subject areas

  • Transplantation

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