TY - JOUR
T1 - Hepatitis C in liver transplantation
T2 - preliminary study of prognostic factors
AU - Nery, J.
AU - Esquenazi, V.
AU - Weppler, D.
AU - Gomez, C.
AU - Cirocco, R.
AU - Gharagozloo, H.
AU - Zucker, K.
AU - Casella, J.
AU - Faria, W.
AU - Carreno, M.
AU - Smith, J.
AU - Markow, M.
AU - Allouch, M.
AU - Babischkin, S.
AU - Bourke, G.
AU - Miller, Joshua
AU - Reddy, R.
AU - Parker, T.
AU - Jeffers, L.
AU - Hill, M.
AU - LaRue, S.
AU - Schiff, E.
PY - 1994/12
Y1 - 1994/12
N2 - Abstract At the University of Miami liver transplantation for chronic liver disease in HCV‐positive patients has shown good results, with a 92% patients survival rate (follow up 8 to 57 months, median 21). None the less, we found that a large number of patients are expected to develop serious histological graft damage and may need retransplantation, which may place a further strain on the already scarce donor resources. We have conducted a preliminary investigation on the importance of parameters which may correlate with the prognosis of HCV grafts. We found no impact of HLA match or typing. An interesting hypothesis, which deserves further investigation, is that some HCV strains could be more virulent than others and play a role as an independent risk factor. We have identified six strains among our patients and the BK serotype shows a trend to be associated with a worse outcome. We have found that patients developing and maintaining higher liver enzyme levels (ALT and GGT) after transplant and those with higher levels of viremia may be at risk to develop serious damage to their grafts.
AB - Abstract At the University of Miami liver transplantation for chronic liver disease in HCV‐positive patients has shown good results, with a 92% patients survival rate (follow up 8 to 57 months, median 21). None the less, we found that a large number of patients are expected to develop serious histological graft damage and may need retransplantation, which may place a further strain on the already scarce donor resources. We have conducted a preliminary investigation on the importance of parameters which may correlate with the prognosis of HCV grafts. We found no impact of HLA match or typing. An interesting hypothesis, which deserves further investigation, is that some HCV strains could be more virulent than others and play a role as an independent risk factor. We have identified six strains among our patients and the BK serotype shows a trend to be associated with a worse outcome. We have found that patients developing and maintaining higher liver enzyme levels (ALT and GGT) after transplant and those with higher levels of viremia may be at risk to develop serious damage to their grafts.
KW - Hepatitis C
KW - Liver transplantation
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U2 - 10.1111/j.1432-2277.1994.tb01354.x
DO - 10.1111/j.1432-2277.1994.tb01354.x
M3 - Article
C2 - 11271211
AN - SCOPUS:0028676589
SN - 0934-0874
VL - 7
SP - 229
EP - 231
JO - Transplant International
JF - Transplant International
ER -