Hepatobiliary Complications in Critically Ill Patients

Amanda Cheung*, Steven Flamm

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Critically ill patients frequently present with the systemic inflammatory response syndrome, which is largely a reflection of the liver's response to injury. Underlying hepatic congestion is a major risk factor for hypoxic liver injury, the most common cause for hepatocellular injury. Cholestatic liver injury often occurs in critically ill patients due to inhibition of farnesoid X receptor (FXR), the main regulator of bile acid handling, particularly in the liver and intestines. Additional injury to the liver occurs due to alterations in the bile acid pool with increased cytotoxic forms and disturbance in the typical processing of xenobiotics in the liver.

Original languageEnglish (US)
Pages (from-to)221-232
Number of pages12
JournalClinics in liver disease
Volume23
Issue number2
DOIs
StatePublished - May 2019

Keywords

  • Acute liver failure
  • Acute liver injury
  • Cholestatic liver injury
  • Critical illness
  • Hepatobiliary
  • Hypoxic liver injury

ASJC Scopus subject areas

  • Hepatology

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