Hepatobiliary Complications of Hematopoietic Cell Transplantation

Josh Levitsky*, Natasha Walzer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hepatobiliary disorders are a leading cause of morbidity and mortality following hematopoietic cell transplantation (HCT), even with recent advances in prophylaxis, diagnosis, and treatment. Critical to reducing the incidence of these complications is adequate screening of donors and recipients for prior or active viral infections or evidence of liver disease, as well as close monitoring for signs and symptoms of hepatic dysfunction after HCT. The most common hepatobiliary etiologies include acute and chronic graft-versus-host disease, sinusoidal obstruction syndrome, drug toxicity, infection (bacterial and viral hepatitis), and cholelithiasis. This chapter emphasizes the importance of donor and recipient evaluation and reviews the prevention, diagnosis, and treatment of common and uncommon liver and biliary complications following HCT.

Original languageEnglish (US)
Title of host publicationSchiff's Diseases of the Liver
PublisherWiley Blackwell
Pages255-270
Number of pages16
ISBN (Print)0470654686, 9780470654682
DOIs
StatePublished - Oct 31 2011

Keywords

  • Cytomegalovirus
  • Epstein-Barr virus
  • Graft-versus-host disease
  • Hepatic venous pressure gradient
  • Hepatitis B virus reactivation
  • Hepatitis C virus
  • Herpesvirus
  • Iron overload
  • Sinusoidal obstruction syndrome
  • Venocclusive disease

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Levitsky, J., & Walzer, N. (2011). Hepatobiliary Complications of Hematopoietic Cell Transplantation. In Schiff's Diseases of the Liver (pp. 255-270). Wiley Blackwell. https://doi.org/10.1002/9781119950509.ch10