Hepatocellular ultrastructure after ischemia/reperfusion injury in human orthotopic liver transplantation

Satish N. Nadig, Basker Periyasamy, Stephen F. Shafizadeh, Carmen Polito, Ryan N. Fiorini, David Rodwell, Zachary Evans, Gang Cheng, Dana Dunkelberger, Michael Schmidt, Sally E. Self, Kenneth D. Chavin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The number of patients requiring organ transplants still outpaces the number of available transplantable organs. During the process of orthotopic liver transplantation (OLTx), donor organs undergo significant stress resulting from ischemia and reperfusion. Healthy organs respond to this stressful environment with compensatory mechanisms that ideally allow for complete recovery. However, "marginal" organs do not compensate as well. Hepatic steatosis typically renders an organ nontransplantable; a liver with 30% or more fat has a 25% chance of primary nonfunction (PNF) or graft failure after a technically sound operation. In this study, we report on the significant markers of cellular ultrastructural change in steatotic livers. These include glycogen content, mitochondrial swelling, and hepatocellular blebbing. The data disclosed here argue that further investigation of these factors in marginal organs subjected to I/R may better facilitate our understanding of PNF.

Original languageEnglish (US)
Pages (from-to)695-700
Number of pages6
JournalJournal of Gastrointestinal Surgery
Issue number6
StatePublished - Sep 10 2004
Externally publishedYes


  • Mitochondrial swelling
  • primary nonfunction
  • steatosis
  • transmission electron microscopy (TEM)
  • ultrastructural changes

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


Dive into the research topics of 'Hepatocellular ultrastructure after ischemia/reperfusion injury in human orthotopic liver transplantation'. Together they form a unique fingerprint.

Cite this