Hepatocyte migration during liver development requires Prox1

Beatriz Sosa-Pineda; Jeffrey T. Wigle; Guillermo Oliver

doi:10.1038/76996

Hepatocyte migration during liver development requires Prox1

Beatriz Sosa-Pineda, Jeffrey T. Wigle, Guillermo Oliver^*

^*Corresponding author for this work

Medicine, Nephrology Division

Research output: Contribution to journal › Article › peer-review

316 Scopus citations

Original language	English (US)
Pages (from-to)	254-255
Number of pages	2
Journal	Nature Genetics
Volume	25
Issue number	3
DOIs	https://doi.org/10.1038/76996
State	Published - Jul 2000

ASJC Scopus subject areas

Genetics

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title = "Hepatocyte migration during liver development requires Prox1",

author = "Beatriz Sosa-Pineda and Wigle, {Jeffrey T.} and Guillermo Oliver",

note = "Funding Information: liver (Fig. 1k,m). Analysis of E14.5 liver cells by fluorescence-activated cell sorting showed no differences between the myeloid and lymphoid cell populations of wild-type and Prox1–/– embryos (data not shown). Genes controlling different steps of liver morphogenesis (c-jun, SF/HGF, c-met) have been identi- fied1. RT–PCR analysis showed no significant differences in their expression in Prox1–/– liver (data not shown). Our findings indicate that Prox1 controls hepatocyte migration from the endodermal epithelium into the septum transversum. This possibility is supported by the arrest in lymphatic endothelial cell budding and sprouting found in Prox1–/– embryos12. Impaired migration of Prox1–/– hepatocytes",

year = "2000",

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doi = "10.1038/76996",

language = "English (US)",

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pages = "254--255",

journal = "Nature Genetics",

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T1 - Hepatocyte migration during liver development requires Prox1

AU - Sosa-Pineda, Beatriz

AU - Wigle, Jeffrey T.

AU - Oliver, Guillermo

N1 - Funding Information: liver (Fig. 1k,m). Analysis of E14.5 liver cells by fluorescence-activated cell sorting showed no differences between the myeloid and lymphoid cell populations of wild-type and Prox1–/– embryos (data not shown). Genes controlling different steps of liver morphogenesis (c-jun, SF/HGF, c-met) have been identi- fied1. RT–PCR analysis showed no significant differences in their expression in Prox1–/– liver (data not shown). Our findings indicate that Prox1 controls hepatocyte migration from the endodermal epithelium into the septum transversum. This possibility is supported by the arrest in lymphatic endothelial cell budding and sprouting found in Prox1–/– embryos12. Impaired migration of Prox1–/– hepatocytes

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Hepatocyte migration during liver development requires Prox1

ASJC Scopus subject areas

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