Hepatorenal Syndrome: Physiology, Diagnosis and Management

Joseph Chmielewski, Robert J. Lewandowski, Haripriya Maddur*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations


Individuals with end-stage liver disease are susceptible to a myriad of highly morbid complications, including hepatorenal syndrome (HRS). This specific type of renal dysfunction in patients with underlying liver disease occurs in pathophysiologically normal kidneys and is a result of renal vasoconstriction secondary to diminished renal blood flow in the setting of worsening hepatic dysfunction. Liver transplantation is curative; shortage of available organs limits access to this beneficial therapy. Medical management of HRS has demonstrated increasing promise. Transjugular intrahepatic portosystemic shunt creation has also been shown to be efficacious in enhancing transplant-free survival, although further study is advisable before widespread implementation of this strategy.

Original languageEnglish (US)
Pages (from-to)194-197
Number of pages4
JournalSeminars in Interventional Radiology
Issue number3
StatePublished - Jan 1 2018


  • TIPS
  • hepatorenal syndrome
  • pathophysiology
  • terlipressin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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