Hepatosplenic gamma-delta T-cell lymphoma: Clinicopathological features and treatment

G. S. Falchook, F. Vega, N. H. Dang, F. Samaniego, M. A. Rodriguez, R. E. Champlin, C. Hosing, S. Verstovsek, B. Pro*

*Corresponding author for this work

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

Background: Hepatosplenic T-cell lymphoma (HSTCL) is a rare peripheral T-cell lymphoma; treatment with standard anthracycline-containing chemotherapy regimens has been disappointing, and an optimal treatment strategy for this patient population has not yet been determined. Methods: We identified 15 cases of pathologically confirmed HSTCL in the institution's database. Clinical characteristics and treatment results were reviewed. Results: Complete responses (CRs) were achieved in 7 of 14 patients who received chemotherapy. Achievement of CR was followed by hematopoietic stem-cell transplantation in three patients. Median duration of CR was 8 months (range 2 to 32+ months) with four patients currently alive and in CR at 5, 8, 12, and 32 months, respectively. Median overall survival (OS) was 11 months (range 2 to 36+ months). Patients who achieved a CR had a median OS of 13 months, compared with 7.5 months in patients who did not achieve a CR. Risk factors associated with worse outcome included male gender, failure to achieve a CR, history of immunocompromise, and absence of a T-cell receptor gene rearrangement in the gamma chain. Conclusion: A better understanding of the pathophysiology of HSTCL and new therapeutic strategies are needed.

Original languageEnglish (US)
Pages (from-to)1080-1085
Number of pages6
JournalAnnals of Oncology
Volume20
Issue number6
DOIs
StatePublished - Jun 4 2009

Keywords

  • Clinicopathological features
  • Hematopoietic stem-cell transplantation
  • Hepatosplenic T-cell lymphoma
  • Treatment

ASJC Scopus subject areas

  • Hematology
  • Oncology

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