HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth

Issam Ben-Sahra, Alexandre Puissant*

*Corresponding author for this work

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

Alteration of cell energy metabolism represents a major determinant of cancer progression; however, our understanding of oncogenic mechanisms underlying this rewiring remains elusive. In this issue of Cell Metabolism, Kurmi et al. (2018) show that HER2 signaling promotes ABL-mediated phosphorylation of the mitochondrial creatine kinase (MtCK1), providing ATP to support breast tumor growth. Alteration of cell energy metabolism represents a major determinant of cancer progression; however, our understanding of oncogenic mechanisms underlying this rewiring remains elusive. In this issue of Cell Metabolism, Kurmi et al. (2018) show that HER2 signaling promotes ABL-mediated phosphorylation of the mitochondrial creatine kinase (MtCK1), providing ATP to support breast tumor growth.

Original languageEnglish (US)
Pages (from-to)805-807
Number of pages3
JournalCell Metabolism
Volume28
Issue number6
DOIs
StatePublished - Dec 4 2018

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ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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