Abstract
Alteration of cell energy metabolism represents a major determinant of cancer progression; however, our understanding of oncogenic mechanisms underlying this rewiring remains elusive. In this issue of Cell Metabolism, Kurmi et al. (2018) show that HER2 signaling promotes ABL-mediated phosphorylation of the mitochondrial creatine kinase (MtCK1), providing ATP to support breast tumor growth. Alteration of cell energy metabolism represents a major determinant of cancer progression; however, our understanding of oncogenic mechanisms underlying this rewiring remains elusive. In this issue of Cell Metabolism, Kurmi et al. (2018) show that HER2 signaling promotes ABL-mediated phosphorylation of the mitochondrial creatine kinase (MtCK1), providing ATP to support breast tumor growth.
Original language | English (US) |
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Pages (from-to) | 805-807 |
Number of pages | 3 |
Journal | Cell Metabolism |
Volume | 28 |
Issue number | 6 |
DOIs | |
State | Published - Dec 4 2018 |
ASJC Scopus subject areas
- Physiology
- Molecular Biology
- Cell Biology