Hereditary Breast and Ovarian Cancer (HBOC): Clinical Features and Counseling for BRCA1 and BRCA2, Lynch Syndrome, Cowden Syndrome, and Li-Fraumeni Syndrome

Lee P. Shulman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

This article provides an overview of the molecular changes associated with inherited gynecologic malignancies and the incorporation of this information in the counseling of individuals at increased risk for developing malignancies, as well as conventional and emerging approaches to the screening of the general population. Cancer genetic counseling and its role in women's health care is examined. The focus is hereditary breast and ovarian cancer; however, cancer predisposition caused by genes other than BRCA1 and BRCA2 is also considered. The aim is to provide a foundation for counseling based on fundamental knowledge of the genes and their clinical consequences. The reader is then guided through the mechanics of risk assessment for individual patients, concluding with the psychosocial implications of counseling.

Original languageEnglish (US)
Pages (from-to)109-133
Number of pages25
JournalObstetrics and Gynecology Clinics of North America
Volume37
Issue number1
DOIs
StatePublished - Mar 1 2010

Keywords

  • BRCA1/2
  • Genetic counseling
  • Hereditary breast cancer
  • Hereditary ovarian cancer
  • Lynch syndrome

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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