Hereditary dysfunction of voltage-gated sodium channels: From clinical phenotype to molecular mechanisms

Alfred L. George*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Genetic disorders of ion channel function are being increasingly recognized due to advances in molecular genetic techniques. Disorders such as those illustrated herein, offer unique opportunities to correlate clinical phenotypes to specific physiological disturbances at the molecular level. These advances in understanding pathophysiology will almost certainly lead to more rationale drug therapy, improved diagnosis, and a more complete appreciation for the importance of ion channels in health and disease.

Original languageEnglish (US)
Pages (from-to)1730-1737
Number of pages8
JournalNephrology Dialysis Transplantation
Volume11
Issue number9
DOIs
StatePublished - Sep 1996

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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