Hereditary multiple exostosis and pain

Sandra Darilek, Catherine Wicklund, Diane Novy, Allison Scott, Michael Gambello, Dennis Johnston, Jacqueline Hecht*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


This study was undertaken to characterize pain in individuals with hereditary multiple exostosis (HME). Two hundred ninety-three patients with HME completed a questionnaire designed to assess pain as well as its impact on their life. Eighty-four percent of participants reported having pain, indicating that pain is a real problem in HME. Of those with pain, 55.1% had generalized pain. Two factors were found to be associated with pain outcome: HME-related complications and surgery. Individuals who had HME-related complications were five times more likely to have pain, while those who had surgery were 3.8 more likely to have pain. No differences were found between males and females with respect to pain, surgery, or HME-related complications. The results of this study indicate that the number of individuals with HME who have pain has been underestimated and that pain is a problem that must be addressed when caring for individuals with HME.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalJournal of Pediatric Orthopaedics
Issue number3
StatePublished - May 2005


  • Exostoses
  • Hereditary multiple exostosis
  • Osteochondromas
  • Pain
  • Support group

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Orthopedics and Sports Medicine


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