Herpes simplex type 2 in a patient with Mollaret's meningitis: Demonstration by polymerase chain reaction

Bruce Arnold Cohen*, Anne H Rowley, Christopher M. Long

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

We describe a patient with recurrent self‐limited aseptic meningitis meeting the criteria for Mollaret's syndrome, in whom extensive serological investigation and cerebrospinal fluid analysis failed to reveal a specific cause. Using polymerase chain reaction techniques to amplify herpes simplex viral DNA, we were able to identify the presence of herpes simplex virus type 2 in the cerebrospinal fluid. The duration of clinical illness may have been shortened by treatment with intravenous acyclovir. We suggest that herpes simplex virus may be a more common cause of aseptic meningitis than has been demonstrated by current commonly available serological and culture techniques.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalAnnals of neurology
Volume35
Issue number1
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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