Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS Cohort Study

Rulin C. Hechter; Matthew Budoff; Howard N. Hodis; Charles R. Rinaldo; Frank J. Jenkins; Lisa P. Jacobson; Lawrence A. Kingsley; Babafemi Taiwo; Wendy S. Post; Joseph B. Margolick; Roger Detels

doi:10.1016/j.atherosclerosis.2012.03.002

Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS Cohort Study

Rulin C. Hechter^*, Matthew Budoff, Howard N. Hodis, Charles R. Rinaldo, Frank J. Jenkins, Lisa P. Jacobson, Lawrence A. Kingsley, Babafemi Taiwo, Wendy S. Post, Joseph B. Margolick, Roger Detels

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

We assessed associations of herpes simplex virus types 1 and 2 (HSV-1 and -2), cytomegalovirus (CMV), and human herpesvirus 8 (HHV-8) infection with subclinical coronary atherosclerosis in 291 HIV-infected men in the Multicenter AIDS Cohort Study. Coronary artery calcium (CAC) was measured by non-contrast coronary CT imaging. Markers for herpesviruses infection were measured in frozen specimens collected 10-12 years prior to case identification. Multivariable logistic regression models and ordinal logistic regression models were performed. HSV-2 seropositivity was associated with coronary atherosclerosis (adjusted odds ratio [AOR] = 4.12, 95% confidence interval [CI]=1.58-10.85) after adjustment for age, race/ethnicity, cardiovascular risk factors, and HIV infection related factors. Infection with a greater number of herpesviruses was associated with elevated CAC levels (AOR=1.58, 95% CI = 1.06-2.36). Our findings suggest HSV-2 may be a risk factor for subclinical coronary atherosclerosis in HIV-infected men. Infection with multiple herpesviruses may contribute to the increased burden of atherosclerosis.

Original language	English (US)
Pages (from-to)	433-436
Number of pages	4
Journal	Atherosclerosis
Volume	223
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2012.03.002
State	Published - Aug 2012

Funding

Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS) with centers (principal investigators) at The Johns Hopkins Bloomberg School of Public Health (Joseph B. Margolick, Lisa P. Jacobson); Howard Brown Health Center, Feinberg School of Medicine, Northwestern University and Cook County Bureau of Health Services (John P. Phair, Steven M. Wolinsky); UCLA (Roger Detels); and University of Pittsburgh (Charles R. Rinaldo). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute : UO1-AI-35042 , UL1-RR025005 (GCRC) , UO1-AI-35043 , UO1-AI-35039 , UO1-AI-35040 , UO1-AI-35041 [ http://www.statepi.jhsph.edu/macs/macs.html ].

Keywords

Atherosclerosis
HIV-1/AIDS
HSV-2
Herpesvirus
Risk factors

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.atherosclerosis.2012.03.002

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Hechter, R. C., Budoff, M., Hodis, H. N., Rinaldo, C. R., Jenkins, F. J., Jacobson, L. P., Kingsley, L. A., Taiwo, B., Post, W. S., Margolick, J. B., & Detels, R. (2012). Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS Cohort Study. Atherosclerosis, 223(2), 433-436. https://doi.org/10.1016/j.atherosclerosis.2012.03.002

@article{d2fac63fcffb4da4ad0a0ab3dd01dba9,

title = "Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS Cohort Study",

abstract = "We assessed associations of herpes simplex virus types 1 and 2 (HSV-1 and -2), cytomegalovirus (CMV), and human herpesvirus 8 (HHV-8) infection with subclinical coronary atherosclerosis in 291 HIV-infected men in the Multicenter AIDS Cohort Study. Coronary artery calcium (CAC) was measured by non-contrast coronary CT imaging. Markers for herpesviruses infection were measured in frozen specimens collected 10-12 years prior to case identification. Multivariable logistic regression models and ordinal logistic regression models were performed. HSV-2 seropositivity was associated with coronary atherosclerosis (adjusted odds ratio [AOR] = 4.12, 95% confidence interval [CI]=1.58-10.85) after adjustment for age, race/ethnicity, cardiovascular risk factors, and HIV infection related factors. Infection with a greater number of herpesviruses was associated with elevated CAC levels (AOR=1.58, 95% CI = 1.06-2.36). Our findings suggest HSV-2 may be a risk factor for subclinical coronary atherosclerosis in HIV-infected men. Infection with multiple herpesviruses may contribute to the increased burden of atherosclerosis.",

keywords = "Atherosclerosis, HIV-1/AIDS, HSV-2, Herpesvirus, Risk factors",

author = "Hechter, {Rulin C.} and Matthew Budoff and Hodis, {Howard N.} and Rinaldo, {Charles R.} and Jenkins, {Frank J.} and Jacobson, {Lisa P.} and Kingsley, {Lawrence A.} and Babafemi Taiwo and Post, {Wendy S.} and Margolick, {Joseph B.} and Roger Detels",

note = "Funding Information: Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS) with centers (principal investigators) at The Johns Hopkins Bloomberg School of Public Health (Joseph B. Margolick, Lisa P. Jacobson); Howard Brown Health Center, Feinberg School of Medicine, Northwestern University and Cook County Bureau of Health Services (John P. Phair, Steven M. Wolinsky); UCLA (Roger Detels); and University of Pittsburgh (Charles R. Rinaldo). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute : UO1-AI-35042 , UL1-RR025005 (GCRC) , UO1-AI-35043 , UO1-AI-35039 , UO1-AI-35040 , UO1-AI-35041 [ http://www.statepi.jhsph.edu/macs/macs.html ]. ",

year = "2012",

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doi = "10.1016/j.atherosclerosis.2012.03.002",

language = "English (US)",

volume = "223",

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journal = "Atherosclerosis",

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Hechter, RC, Budoff, M, Hodis, HN, Rinaldo, CR, Jenkins, FJ, Jacobson, LP, Kingsley, LA, Taiwo, B, Post, WS, Margolick, JB & Detels, R 2012, 'Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS Cohort Study', Atherosclerosis, vol. 223, no. 2, pp. 433-436. https://doi.org/10.1016/j.atherosclerosis.2012.03.002

TY - JOUR

T1 - Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men

T2 - Multicenter AIDS Cohort Study

AU - Hechter, Rulin C.

AU - Budoff, Matthew

AU - Hodis, Howard N.

AU - Rinaldo, Charles R.

AU - Jenkins, Frank J.

AU - Jacobson, Lisa P.

AU - Kingsley, Lawrence A.

AU - Taiwo, Babafemi

AU - Post, Wendy S.

AU - Margolick, Joseph B.

AU - Detels, Roger

N1 - Funding Information: Data in this manuscript were collected by the Multicenter AIDS Cohort Study (MACS) with centers (principal investigators) at The Johns Hopkins Bloomberg School of Public Health (Joseph B. Margolick, Lisa P. Jacobson); Howard Brown Health Center, Feinberg School of Medicine, Northwestern University and Cook County Bureau of Health Services (John P. Phair, Steven M. Wolinsky); UCLA (Roger Detels); and University of Pittsburgh (Charles R. Rinaldo). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute : UO1-AI-35042 , UL1-RR025005 (GCRC) , UO1-AI-35043 , UO1-AI-35039 , UO1-AI-35040 , UO1-AI-35041 [ http://www.statepi.jhsph.edu/macs/macs.html ].

PY - 2012/8

Y1 - 2012/8

N2 - We assessed associations of herpes simplex virus types 1 and 2 (HSV-1 and -2), cytomegalovirus (CMV), and human herpesvirus 8 (HHV-8) infection with subclinical coronary atherosclerosis in 291 HIV-infected men in the Multicenter AIDS Cohort Study. Coronary artery calcium (CAC) was measured by non-contrast coronary CT imaging. Markers for herpesviruses infection were measured in frozen specimens collected 10-12 years prior to case identification. Multivariable logistic regression models and ordinal logistic regression models were performed. HSV-2 seropositivity was associated with coronary atherosclerosis (adjusted odds ratio [AOR] = 4.12, 95% confidence interval [CI]=1.58-10.85) after adjustment for age, race/ethnicity, cardiovascular risk factors, and HIV infection related factors. Infection with a greater number of herpesviruses was associated with elevated CAC levels (AOR=1.58, 95% CI = 1.06-2.36). Our findings suggest HSV-2 may be a risk factor for subclinical coronary atherosclerosis in HIV-infected men. Infection with multiple herpesviruses may contribute to the increased burden of atherosclerosis.

AB - We assessed associations of herpes simplex virus types 1 and 2 (HSV-1 and -2), cytomegalovirus (CMV), and human herpesvirus 8 (HHV-8) infection with subclinical coronary atherosclerosis in 291 HIV-infected men in the Multicenter AIDS Cohort Study. Coronary artery calcium (CAC) was measured by non-contrast coronary CT imaging. Markers for herpesviruses infection were measured in frozen specimens collected 10-12 years prior to case identification. Multivariable logistic regression models and ordinal logistic regression models were performed. HSV-2 seropositivity was associated with coronary atherosclerosis (adjusted odds ratio [AOR] = 4.12, 95% confidence interval [CI]=1.58-10.85) after adjustment for age, race/ethnicity, cardiovascular risk factors, and HIV infection related factors. Infection with a greater number of herpesviruses was associated with elevated CAC levels (AOR=1.58, 95% CI = 1.06-2.36). Our findings suggest HSV-2 may be a risk factor for subclinical coronary atherosclerosis in HIV-infected men. Infection with multiple herpesviruses may contribute to the increased burden of atherosclerosis.

KW - Atherosclerosis

KW - HIV-1/AIDS

KW - HSV-2

KW - Herpesvirus

KW - Risk factors

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U2 - 10.1016/j.atherosclerosis.2012.03.002

DO - 10.1016/j.atherosclerosis.2012.03.002

M3 - Article

C2 - 22472456

AN - SCOPUS:84864767476

SN - 0021-9150

VL - 223

SP - 433

EP - 436

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS Cohort Study

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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