Herpes simplex virus type 2 (HSV-2) as a coronary atherosclerosis risk factor in HIV-infected men: Multicenter AIDS Cohort Study

Rulin C. Hechter*, Matthew Budoff, Howard N. Hodis, Charles R. Rinaldo, Frank J. Jenkins, Lisa P. Jacobson, Lawrence A. Kingsley, Babafemi Taiwo, Wendy S. Post, Joseph B. Margolick, Roger Detels

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We assessed associations of herpes simplex virus types 1 and 2 (HSV-1 and -2), cytomegalovirus (CMV), and human herpesvirus 8 (HHV-8) infection with subclinical coronary atherosclerosis in 291 HIV-infected men in the Multicenter AIDS Cohort Study. Coronary artery calcium (CAC) was measured by non-contrast coronary CT imaging. Markers for herpesviruses infection were measured in frozen specimens collected 10-12 years prior to case identification. Multivariable logistic regression models and ordinal logistic regression models were performed. HSV-2 seropositivity was associated with coronary atherosclerosis (adjusted odds ratio [AOR] = 4.12, 95% confidence interval [CI]=1.58-10.85) after adjustment for age, race/ethnicity, cardiovascular risk factors, and HIV infection related factors. Infection with a greater number of herpesviruses was associated with elevated CAC levels (AOR=1.58, 95% CI = 1.06-2.36). Our findings suggest HSV-2 may be a risk factor for subclinical coronary atherosclerosis in HIV-infected men. Infection with multiple herpesviruses may contribute to the increased burden of atherosclerosis.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalAtherosclerosis
Volume223
Issue number2
DOIs
StatePublished - Aug 2012

Keywords

  • Atherosclerosis
  • HIV-1/AIDS
  • HSV-2
  • Herpesvirus
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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