Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines among Sexual and Gender Minorities Living with and Without HIV-1 from Lagos, Nigeria

Meropi Aravantinou; Marlena Plagianos; Afoke Kokogho; Sylvia Adebajo; Rebecca G. Nowak; Elizabeth Shoyemi; Charles Ekeh; Kara Lombardi; Sheila A. Peel; Stefan D. Baral; Trevor A. Crowell; Nina Derby; Natalia Teleshova; Elena Martinelli

doi:10.1089/aid.2022.0070

Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines among Sexual and Gender Minorities Living with and Without HIV-1 from Lagos, Nigeria

Meropi Aravantinou, Marlena Plagianos, Afoke Kokogho, Sylvia Adebajo, Rebecca G. Nowak, Elizabeth Shoyemi, Charles Ekeh, Kara Lombardi, Sheila A. Peel, Stefan D. Baral, Trevor A. Crowell, Nina Derby, Natalia Teleshova, Elena Martinelli^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Herpes simplex virus type 2 (HSV-2) is common globally and contributes significantly to the risk of acquiring HIV-1, yet these two sexually transmitted infections have not been sufficiently characterized for sexual and gender minorities (SGM) across Sub-Saharan Africa. To help fill this gap, we performed a retrospective study using plasma and serum samples from 183 SGM enrolled at the Lagos site of the TRUST/RV368 cohort in Nigeria, assayed them for HSV-2 antibodies with the Kalon ELISA and plasma cytokines and chemokines with Luminex, and correlated the findings with HIV-1 viral loads (VLs) and CD4 counts. We found an overall HSV-2 prevalence of 36.6% (49.5% and 23.9% among SGM with and without HIV-1, respectively, p < .001). Moreover, HSV-2-positive status was associated with high circulating concentrations of CCL11 among antiretroviral therapy-Treated (p = .031) and untreated (p = .015) participants, and with high concentrations of CCL2 in the untreated group (p = .004), independent of VL. Principal component analysis revealed a strong association of cytokines with HIV-1 VL independent of HSV-2 status. In conclusion, our study finds that HSV-2 prevalence among SGM with HIV-1 is twice as high than HSV-2 prevalence among SGM without HIV-1 in Lagos and suggests that this is associated with higher levels of certain systemic cytokines. Additional work is needed to further characterize the relationship between HSV-2 and HIV-1 in SGM and help develop targeted therapies for coinfected individuals.

Original language	English (US)
Pages (from-to)	485-494
Number of pages	10
Journal	AIDS research and human retroviruses
Volume	39
Issue number	9
DOIs	https://doi.org/10.1089/aid.2022.0070
State	Published - Sep 1 2023

Funding

This work was supported by a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense [W81XWH-11-2-0174, W81XWH-18-2-0040]; the National Institutes of Health [R03 AI170156; R01 MH099001, R01 AI120913, R01 MH110358, K07CA225403]; Fogarty Epidemiology Research Training for Public Health Impact in Nigeria program [D43TW010051]; and the President's Emergency Plan for AIDS Relief through a cooperative agreement between the Department of Health and Human Services/Centers for Disease Control and Prevention, Global AIDS Program, and the Institute for Human Virology-Nigeria [NU2GGH002099]. Financial support for this study was provided by the Population Council.

Keywords

HIV
HSV-2
STI
anorectal
inflammation

ASJC Scopus subject areas

Infectious Diseases
Virology
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/aid.2022.0070

Cite this

Aravantinou, M., Plagianos, M., Kokogho, A., Adebajo, S., Nowak, R. G., Shoyemi, E., Ekeh, C., Lombardi, K., Peel, S. A., Baral, S. D., Crowell, T. A., Derby, N., Teleshova, N., & Martinelli, E. (2023). Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines among Sexual and Gender Minorities Living with and Without HIV-1 from Lagos, Nigeria. AIDS research and human retroviruses, 39(9), 485-494. https://doi.org/10.1089/aid.2022.0070

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title = "Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines among Sexual and Gender Minorities Living with and Without HIV-1 from Lagos, Nigeria",

abstract = "Herpes simplex virus type 2 (HSV-2) is common globally and contributes significantly to the risk of acquiring HIV-1, yet these two sexually transmitted infections have not been sufficiently characterized for sexual and gender minorities (SGM) across Sub-Saharan Africa. To help fill this gap, we performed a retrospective study using plasma and serum samples from 183 SGM enrolled at the Lagos site of the TRUST/RV368 cohort in Nigeria, assayed them for HSV-2 antibodies with the Kalon ELISA and plasma cytokines and chemokines with Luminex, and correlated the findings with HIV-1 viral loads (VLs) and CD4 counts. We found an overall HSV-2 prevalence of 36.6% (49.5% and 23.9% among SGM with and without HIV-1, respectively, p < .001). Moreover, HSV-2-positive status was associated with high circulating concentrations of CCL11 among antiretroviral therapy-Treated (p = .031) and untreated (p = .015) participants, and with high concentrations of CCL2 in the untreated group (p = .004), independent of VL. Principal component analysis revealed a strong association of cytokines with HIV-1 VL independent of HSV-2 status. In conclusion, our study finds that HSV-2 prevalence among SGM with HIV-1 is twice as high than HSV-2 prevalence among SGM without HIV-1 in Lagos and suggests that this is associated with higher levels of certain systemic cytokines. Additional work is needed to further characterize the relationship between HSV-2 and HIV-1 in SGM and help develop targeted therapies for coinfected individuals.",

keywords = "HIV, HSV-2, STI, anorectal, inflammation",

author = "Meropi Aravantinou and Marlena Plagianos and Afoke Kokogho and Sylvia Adebajo and Nowak, {Rebecca G.} and Elizabeth Shoyemi and Charles Ekeh and Kara Lombardi and Peel, {Sheila A.} and Baral, {Stefan D.} and Crowell, {Trevor A.} and Nina Derby and Natalia Teleshova and Elena Martinelli",

note = "Publisher Copyright: Copyright {\textcopyright} 2023, Mary Ann Liebert, Inc., publishers 2023.",

year = "2023",

month = sep,

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doi = "10.1089/aid.2022.0070",

language = "English (US)",

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Aravantinou, M, Plagianos, M, Kokogho, A, Adebajo, S, Nowak, RG, Shoyemi, E, Ekeh, C, Lombardi, K, Peel, SA, Baral, SD, Crowell, TA, Derby, N, Teleshova, N & Martinelli, E 2023, 'Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines among Sexual and Gender Minorities Living with and Without HIV-1 from Lagos, Nigeria', AIDS research and human retroviruses, vol. 39, no. 9, pp. 485-494. https://doi.org/10.1089/aid.2022.0070

Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines among Sexual and Gender Minorities Living with and Without HIV-1 from Lagos, Nigeria. / Aravantinou, Meropi; Plagianos, Marlena; Kokogho, Afoke et al.
In: AIDS research and human retroviruses, Vol. 39, No. 9, 01.09.2023, p. 485-494.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines among Sexual and Gender Minorities Living with and Without HIV-1 from Lagos, Nigeria

AU - Aravantinou, Meropi

AU - Plagianos, Marlena

AU - Kokogho, Afoke

AU - Adebajo, Sylvia

AU - Nowak, Rebecca G.

AU - Shoyemi, Elizabeth

AU - Ekeh, Charles

AU - Lombardi, Kara

AU - Peel, Sheila A.

AU - Baral, Stefan D.

AU - Crowell, Trevor A.

AU - Derby, Nina

AU - Teleshova, Natalia

AU - Martinelli, Elena

PY - 2023/9/1

Y1 - 2023/9/1

N2 - Herpes simplex virus type 2 (HSV-2) is common globally and contributes significantly to the risk of acquiring HIV-1, yet these two sexually transmitted infections have not been sufficiently characterized for sexual and gender minorities (SGM) across Sub-Saharan Africa. To help fill this gap, we performed a retrospective study using plasma and serum samples from 183 SGM enrolled at the Lagos site of the TRUST/RV368 cohort in Nigeria, assayed them for HSV-2 antibodies with the Kalon ELISA and plasma cytokines and chemokines with Luminex, and correlated the findings with HIV-1 viral loads (VLs) and CD4 counts. We found an overall HSV-2 prevalence of 36.6% (49.5% and 23.9% among SGM with and without HIV-1, respectively, p < .001). Moreover, HSV-2-positive status was associated with high circulating concentrations of CCL11 among antiretroviral therapy-Treated (p = .031) and untreated (p = .015) participants, and with high concentrations of CCL2 in the untreated group (p = .004), independent of VL. Principal component analysis revealed a strong association of cytokines with HIV-1 VL independent of HSV-2 status. In conclusion, our study finds that HSV-2 prevalence among SGM with HIV-1 is twice as high than HSV-2 prevalence among SGM without HIV-1 in Lagos and suggests that this is associated with higher levels of certain systemic cytokines. Additional work is needed to further characterize the relationship between HSV-2 and HIV-1 in SGM and help develop targeted therapies for coinfected individuals.

AB - Herpes simplex virus type 2 (HSV-2) is common globally and contributes significantly to the risk of acquiring HIV-1, yet these two sexually transmitted infections have not been sufficiently characterized for sexual and gender minorities (SGM) across Sub-Saharan Africa. To help fill this gap, we performed a retrospective study using plasma and serum samples from 183 SGM enrolled at the Lagos site of the TRUST/RV368 cohort in Nigeria, assayed them for HSV-2 antibodies with the Kalon ELISA and plasma cytokines and chemokines with Luminex, and correlated the findings with HIV-1 viral loads (VLs) and CD4 counts. We found an overall HSV-2 prevalence of 36.6% (49.5% and 23.9% among SGM with and without HIV-1, respectively, p < .001). Moreover, HSV-2-positive status was associated with high circulating concentrations of CCL11 among antiretroviral therapy-Treated (p = .031) and untreated (p = .015) participants, and with high concentrations of CCL2 in the untreated group (p = .004), independent of VL. Principal component analysis revealed a strong association of cytokines with HIV-1 VL independent of HSV-2 status. In conclusion, our study finds that HSV-2 prevalence among SGM with HIV-1 is twice as high than HSV-2 prevalence among SGM without HIV-1 in Lagos and suggests that this is associated with higher levels of certain systemic cytokines. Additional work is needed to further characterize the relationship between HSV-2 and HIV-1 in SGM and help develop targeted therapies for coinfected individuals.

KW - HIV

KW - HSV-2

KW - STI

KW - anorectal

KW - inflammation

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ER -

Herpes Simplex Virus Type 2 Prevalence and Association with Inflammatory Cytokines among Sexual and Gender Minorities Living with and Without HIV-1 from Lagos, Nigeria

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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