Herpesvirus entry: An update

Patricia G. Spear*, Richard Longnecker

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

472 Scopus citations


The entry of herpesviruses into cells depends upon interactions of several viral glycoproteins with multiple cell surface receptors. Also, each herpesvirus may have evolved multiple pathways for entry into different cell types, as is evident for HSV and EBV. The broad host range of HSV is consistent with its use of cell surface heparan sulfate as a binding receptor and both 3-O-sulfated heparan sulfate and multiple conserved and widely expressed proteins as entry receptors. The more limited host range of EBV (at least in the case of its B-cell target) is also consistent with its use of binding and entry receptors that are found together on very few cell types, chief of which are B cells. Much remains to be learned about the actual requirements for entry of these viruses into the target cell types that are critical for disease and about the mechanisms of virus-induced membrane fusion.

Original languageEnglish (US)
Pages (from-to)10179-10185
Number of pages7
JournalJournal of virology
Issue number19
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Insect Science
  • Virology
  • Microbiology
  • Immunology


Dive into the research topics of 'Herpesvirus entry: An update'. Together they form a unique fingerprint.

Cite this