TY - JOUR
T1 - Heterochromatin protein 1 expression is reduced in human thyroid malignancy
AU - Tretiakova, Maria S.
AU - Bond, Sarah D.
AU - Wheeler, David
AU - Contreras, Alejandro
AU - Kocherginsky, Masha
AU - Kroll, Todd G.
AU - Hale, Tracy K.
N1 - Funding Information:
This study was supported by grants from the Cancer Society of New Zealand and the Palmerston North Medical Research Foundation. We thank Bruce Lockett and Natisha Magan for critical reading of the manuscript.
PY - 2014/7
Y1 - 2014/7
N2 - Owing to the loss of heterochromatin integrity that occurs during thyroid tumorigenesis, the expression of Heterochromatin Protein 1 isoforms HP1α and HP1β was assessed by immunohistochemistry in 189 thyroid tumors and non-neoplastic tissues. Expression of HP1β was significantly decreased in all thyroid lesions, except in follicular adenomas, when compared with matched adjacent normal tissue. This loss of HP1β expression may in part be caused by microRNA dysregulation. An example is miR-205, a microRNA that is abundantly upregulated in thyroid carcinomas and shown to reduce the expression of HP1β. In contrast to HP1β, HP1α expression was only reduced in metastatic carcinomas and poorly differentiated lesions. These results suggest the reduction of HP1β followed by a decrease in HP1α contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.
AB - Owing to the loss of heterochromatin integrity that occurs during thyroid tumorigenesis, the expression of Heterochromatin Protein 1 isoforms HP1α and HP1β was assessed by immunohistochemistry in 189 thyroid tumors and non-neoplastic tissues. Expression of HP1β was significantly decreased in all thyroid lesions, except in follicular adenomas, when compared with matched adjacent normal tissue. This loss of HP1β expression may in part be caused by microRNA dysregulation. An example is miR-205, a microRNA that is abundantly upregulated in thyroid carcinomas and shown to reduce the expression of HP1β. In contrast to HP1β, HP1α expression was only reduced in metastatic carcinomas and poorly differentiated lesions. These results suggest the reduction of HP1β followed by a decrease in HP1α contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.
KW - heterochromatin protein 1
KW - microRNA
KW - thyroid
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U2 - 10.1038/labinvest.2014.68
DO - 10.1038/labinvest.2014.68
M3 - Article
C2 - 24840329
AN - SCOPUS:84903536343
SN - 0023-6837
VL - 94
SP - 788
EP - 795
JO - Laboratory Investigation
JF - Laboratory Investigation
IS - 7
ER -