Heterochromatin protein 1 expression is reduced in human thyroid malignancy

Maria S. Tretiakova, Sarah D. Bond, David Wheeler, Alejandro Contreras, Masha Kocherginsky, Todd G. Kroll, Tracy K. Hale*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Owing to the loss of heterochromatin integrity that occurs during thyroid tumorigenesis, the expression of Heterochromatin Protein 1 isoforms HP1α and HP1β was assessed by immunohistochemistry in 189 thyroid tumors and non-neoplastic tissues. Expression of HP1β was significantly decreased in all thyroid lesions, except in follicular adenomas, when compared with matched adjacent normal tissue. This loss of HP1β expression may in part be caused by microRNA dysregulation. An example is miR-205, a microRNA that is abundantly upregulated in thyroid carcinomas and shown to reduce the expression of HP1β. In contrast to HP1β, HP1α expression was only reduced in metastatic carcinomas and poorly differentiated lesions. These results suggest the reduction of HP1β followed by a decrease in HP1α contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.

Original languageEnglish (US)
Pages (from-to)788-795
Number of pages8
JournalLaboratory Investigation
Volume94
Issue number7
DOIs
StatePublished - Jan 1 2014

Fingerprint

Thyroid Gland
MicroRNAs
Thyroid Neoplasms
Neoplasms
Heterochromatin
Adenoma
Protein Isoforms
Carcinogenesis
Immunohistochemistry
Carcinoma
heterochromatin-specific nonhistone chromosomal protein HP-1

Keywords

  • heterochromatin protein 1
  • microRNA
  • thyroid

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Tretiakova, M. S., Bond, S. D., Wheeler, D., Contreras, A., Kocherginsky, M., Kroll, T. G., & Hale, T. K. (2014). Heterochromatin protein 1 expression is reduced in human thyroid malignancy. Laboratory Investigation, 94(7), 788-795. https://doi.org/10.1038/labinvest.2014.68
Tretiakova, Maria S. ; Bond, Sarah D. ; Wheeler, David ; Contreras, Alejandro ; Kocherginsky, Masha ; Kroll, Todd G. ; Hale, Tracy K. / Heterochromatin protein 1 expression is reduced in human thyroid malignancy. In: Laboratory Investigation. 2014 ; Vol. 94, No. 7. pp. 788-795.
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Tretiakova, MS, Bond, SD, Wheeler, D, Contreras, A, Kocherginsky, M, Kroll, TG & Hale, TK 2014, 'Heterochromatin protein 1 expression is reduced in human thyroid malignancy', Laboratory Investigation, vol. 94, no. 7, pp. 788-795. https://doi.org/10.1038/labinvest.2014.68

Heterochromatin protein 1 expression is reduced in human thyroid malignancy. / Tretiakova, Maria S.; Bond, Sarah D.; Wheeler, David; Contreras, Alejandro; Kocherginsky, Masha; Kroll, Todd G.; Hale, Tracy K.

In: Laboratory Investigation, Vol. 94, No. 7, 01.01.2014, p. 788-795.

Research output: Contribution to journalArticle

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