Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces

Yuanwen Jiang; João L. Carvalho-De-Souza; Raymond C.S. Wong; Zhiqiang Luo; Dieter Isheim; Xiaobing Zuo; Alan W. Nicholls; Il Woong Jung; Jiping Yue; Di Jia Liu; Yucai Wang; Vincent De Andrade; Xianghui Xiao; Luizetta Navrazhnykh; Dara E. Weiss; Xiaoyang Wu; David N. Seidman; Francisco Bezanilla; Bozhi Tian

doi:10.1038/nmat4673

Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces

Yuanwen Jiang, João L. Carvalho-De-Souza, Raymond C.S. Wong, Zhiqiang Luo, Dieter Isheim, Xiaobing Zuo, Alan W. Nicholls, Il Woong Jung, Jiping Yue, Di Jia Liu, Yucai Wang, Vincent De Andrade, Xianghui Xiao, Luizetta Navrazhnykh, Dara E. Weiss, Xiaoyang Wu, David N. Seidman, Francisco Bezanilla^*, Bozhi Tian

^*Corresponding author for this work

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

Silicon-based materials have widespread application as biophysical tools and biomedical devices. Here we introduce a biocompatible and degradable mesostructured form of silicon with multi-scale structural and chemical heterogeneities. The material was synthesized using mesoporous silica as a template through a chemical vapour deposition process. It has an amorphous atomic structure, an ordered nanowire-based framework and random submicrometre voids, and shows an average Young's modulus that is 2-3 orders of magnitude smaller than that of single-crystalline silicon. In addition, we used the heterogeneous silicon mesostructures to design a lipid-bilayer-supported bioelectric interface that is remotely controlled and temporally transient, and that permits non-genetic and subcellular optical modulation of the electrophysiology dynamics in single dorsal root ganglia neurons. Our findings suggest that the biomimetic expansion of silicon into heterogeneous and deformable forms can open up opportunities in extracellular biomaterial or bioelectric systems.

Original language	English (US)
Pages (from-to)	1023-1030
Number of pages	8
Journal	Nature materials
Volume	15
Issue number	9
DOIs	https://doi.org/10.1038/nmat4673
State	Published - Sep 1 2016

Funding

This work is supported by the Air Force Office of Scientific Research (AFOSR FA9550-14-1-0175, FA9550-15-1-0285), the National Science Foundation (NSF CAREER, DMR-1254637; NSF MRSEC, DMR 1420709), the Searle Scholars Foundation, the National Institutes of Health (NIH GM030376), and the University of Chicago Start-up Fund. Atom-probe tomography was performed at the Northwestern University Center for Atom-Probe Tomography (NUCAPT), whose APT was purchased and upgraded with funding from NSF-MRI (DMR-0420532) and ONR-DURIP (N00014-0400798, N00014-0610539, N00014-0910781) grants.

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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Jiang, Y., Carvalho-De-Souza, J. L., Wong, R. C. S., Luo, Z., Isheim, D., Zuo, X., Nicholls, A. W., Jung, I. W., Yue, J., Liu, D. J., Wang, Y., De Andrade, V., Xiao, X., Navrazhnykh, L., Weiss, D. E., Wu, X., Seidman, D. N., Bezanilla, F., & Tian, B. (2016). Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces. Nature materials, 15(9), 1023-1030. https://doi.org/10.1038/nmat4673

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title = "Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces",

abstract = "Silicon-based materials have widespread application as biophysical tools and biomedical devices. Here we introduce a biocompatible and degradable mesostructured form of silicon with multi-scale structural and chemical heterogeneities. The material was synthesized using mesoporous silica as a template through a chemical vapour deposition process. It has an amorphous atomic structure, an ordered nanowire-based framework and random submicrometre voids, and shows an average Young's modulus that is 2-3 orders of magnitude smaller than that of single-crystalline silicon. In addition, we used the heterogeneous silicon mesostructures to design a lipid-bilayer-supported bioelectric interface that is remotely controlled and temporally transient, and that permits non-genetic and subcellular optical modulation of the electrophysiology dynamics in single dorsal root ganglia neurons. Our findings suggest that the biomimetic expansion of silicon into heterogeneous and deformable forms can open up opportunities in extracellular biomaterial or bioelectric systems.",

author = "Yuanwen Jiang and Carvalho-De-Souza, {Jo{\~a}o L.} and Wong, {Raymond C.S.} and Zhiqiang Luo and Dieter Isheim and Xiaobing Zuo and Nicholls, {Alan W.} and Jung, {Il Woong} and Jiping Yue and Liu, {Di Jia} and Yucai Wang and {De Andrade}, Vincent and Xianghui Xiao and Luizetta Navrazhnykh and Weiss, {Dara E.} and Xiaoyang Wu and Seidman, {David N.} and Francisco Bezanilla and Bozhi Tian",

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Jiang, Y, Carvalho-De-Souza, JL, Wong, RCS, Luo, Z, Isheim, D, Zuo, X, Nicholls, AW, Jung, IW, Yue, J, Liu, DJ, Wang, Y, De Andrade, V, Xiao, X, Navrazhnykh, L, Weiss, DE, Wu, X, Seidman, DN, Bezanilla, F & Tian, B 2016, 'Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces', Nature materials, vol. 15, no. 9, pp. 1023-1030. https://doi.org/10.1038/nmat4673

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AU - Carvalho-De-Souza, João L.

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AU - Zuo, Xiaobing

AU - Nicholls, Alan W.

AU - Jung, Il Woong

AU - Yue, Jiping

AU - Liu, Di Jia

AU - Wang, Yucai

AU - De Andrade, Vincent

AU - Xiao, Xianghui

AU - Navrazhnykh, Luizetta

AU - Weiss, Dara E.

AU - Wu, Xiaoyang

AU - Seidman, David N.

AU - Bezanilla, Francisco

AU - Tian, Bozhi

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Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces

Abstract

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