Heterotopic sternum transplant in rats: A new model of a vascularized bone marrow transplantation

Sergio F. Santiago; Werviston De Faria; Taqi F. Toufeeq Khan; Carlos E. Gandia; Evangelos P. Misiakos; Luis Ferrer; Phillip Ruiz; Laurence Coleman; Hugo F. Fernandez; Joshua Miller; Camillo Ricordi; Andreas G. Tzakis

doi:10.1002/(SICI)1098-2752(1999)19:7<330::AID-MICR8>3.0.CO;2-I

Heterotopic sternum transplant in rats: A new model of a vascularized bone marrow transplantation

Sergio F. Santiago, Werviston De Faria, Taqi F. Toufeeq Khan, Carlos E. Gandia, Evangelos P. Misiakos, Luis Ferrer, Phillip Ruiz, Laurence Coleman, Hugo F. Fernandez, Joshua Miller, Camillo Ricordi, Andreas G. Tzakis^*

^*Corresponding author for this work

Surgery, Transplant Surgery Division

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

We introduced the heterotopic vascularized sternum transplant as a more simple and pure alternative to allogeneic hind limb transplantation for the study of bone marrow transplantation. We report the clinical and histopathological manifestations after transplantation of syngeneic and allogeneic sternal grafts with and without immunossupression with FK-506. Syngeneic grafts maintained normal histology, whereas allografts showed rejection, which was prevented by FK-506. FK-506-treated allografts developed chimerism that was present throughout the observation period. Transplantation of the sternum may be a valuable model to study vascularized bone marrow transplantation and its effects on repopulation of bone marrow of the host, chimerism, and tolerance.

Original language	English (US)
Pages (from-to)	330-334
Number of pages	5
Journal	Microsurgery
Volume	19
Issue number	7
DOIs	https://doi.org/10.1002/(SICI)1098-2752(1999)19:7<330::AID-MICR8>3.0.CO;2-I
State	Published - 1999

Funding

ASJC Scopus subject areas

Surgery

Access to Document

10.1002/(SICI)1098-2752(1999)19:7<330::AID-MICR8>3.0.CO;2-I

Cite this

Santiago, S. F., De Faria, W., Toufeeq Khan, T. F., Gandia, C. E., Misiakos, E. P., Ferrer, L., Ruiz, P., Coleman, L., Fernandez, H. F., Miller, J., Ricordi, C., & Tzakis, A. G. (1999). Heterotopic sternum transplant in rats: A new model of a vascularized bone marrow transplantation. Microsurgery, 19(7), 330-334. https://doi.org/10.1002/(SICI)1098-2752(1999)19:7<330::AID-MICR8>3.0.CO;2-I

@article{2a946c5ec6e14747ab623aecfe8cb9da,

title = "Heterotopic sternum transplant in rats: A new model of a vascularized bone marrow transplantation",

abstract = "We introduced the heterotopic vascularized sternum transplant as a more simple and pure alternative to allogeneic hind limb transplantation for the study of bone marrow transplantation. We report the clinical and histopathological manifestations after transplantation of syngeneic and allogeneic sternal grafts with and without immunossupression with FK-506. Syngeneic grafts maintained normal histology, whereas allografts showed rejection, which was prevented by FK-506. FK-506-treated allografts developed chimerism that was present throughout the observation period. Transplantation of the sternum may be a valuable model to study vascularized bone marrow transplantation and its effects on repopulation of bone marrow of the host, chimerism, and tolerance.",

author = "Santiago, {Sergio F.} and {De Faria}, Werviston and {Toufeeq Khan}, {Taqi F.} and Gandia, {Carlos E.} and Misiakos, {Evangelos P.} and Luis Ferrer and Phillip Ruiz and Laurence Coleman and Fernandez, {Hugo F.} and Joshua Miller and Camillo Ricordi and Tzakis, {Andreas G.}",

year = "1999",

doi = "10.1002/(SICI)1098-2752(1999)19:7<330::AID-MICR8>3.0.CO;2-I",

language = "English (US)",

volume = "19",

pages = "330--334",

journal = "Microsurgery",

issn = "0738-1085",

publisher = "Wiley-Liss Inc.",

number = "7",

}

Santiago, SF, De Faria, W, Toufeeq Khan, TF, Gandia, CE, Misiakos, EP, Ferrer, L, Ruiz, P, Coleman, L, Fernandez, HF, Miller, J, Ricordi, C & Tzakis, AG 1999, 'Heterotopic sternum transplant in rats: A new model of a vascularized bone marrow transplantation', Microsurgery, vol. 19, no. 7, pp. 330-334. https://doi.org/10.1002/(SICI)1098-2752(1999)19:7<330::AID-MICR8>3.0.CO;2-I

TY - JOUR

T1 - Heterotopic sternum transplant in rats

T2 - A new model of a vascularized bone marrow transplantation

AU - Santiago, Sergio F.

AU - De Faria, Werviston

AU - Toufeeq Khan, Taqi F.

AU - Gandia, Carlos E.

AU - Misiakos, Evangelos P.

AU - Ferrer, Luis

AU - Ruiz, Phillip

AU - Coleman, Laurence

AU - Fernandez, Hugo F.

AU - Miller, Joshua

AU - Ricordi, Camillo

AU - Tzakis, Andreas G.

PY - 1999

Y1 - 1999

N2 - We introduced the heterotopic vascularized sternum transplant as a more simple and pure alternative to allogeneic hind limb transplantation for the study of bone marrow transplantation. We report the clinical and histopathological manifestations after transplantation of syngeneic and allogeneic sternal grafts with and without immunossupression with FK-506. Syngeneic grafts maintained normal histology, whereas allografts showed rejection, which was prevented by FK-506. FK-506-treated allografts developed chimerism that was present throughout the observation period. Transplantation of the sternum may be a valuable model to study vascularized bone marrow transplantation and its effects on repopulation of bone marrow of the host, chimerism, and tolerance.

AB - We introduced the heterotopic vascularized sternum transplant as a more simple and pure alternative to allogeneic hind limb transplantation for the study of bone marrow transplantation. We report the clinical and histopathological manifestations after transplantation of syngeneic and allogeneic sternal grafts with and without immunossupression with FK-506. Syngeneic grafts maintained normal histology, whereas allografts showed rejection, which was prevented by FK-506. FK-506-treated allografts developed chimerism that was present throughout the observation period. Transplantation of the sternum may be a valuable model to study vascularized bone marrow transplantation and its effects on repopulation of bone marrow of the host, chimerism, and tolerance.

UR - http://www.scopus.com/inward/record.url?scp=0033405325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033405325&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1098-2752(1999)19:7<330::AID-MICR8>3.0.CO;2-I

DO - 10.1002/(SICI)1098-2752(1999)19:7<330::AID-MICR8>3.0.CO;2-I

M3 - Article

C2 - 10586198

AN - SCOPUS:0033405325

SN - 0738-1085

VL - 19

SP - 330

EP - 334

JO - Microsurgery

JF - Microsurgery

IS - 7

ER -

Heterotopic sternum transplant in rats: A new model of a vascularized bone marrow transplantation

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this